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Primary Founder Mutations in the PRKDC Gene Increase Tumor Mutation Load in Colorectal Cancer

The clonal composition of a malignant tumor strongly depends on cellular dynamics influenced by the asynchronized loss of DNA repair mechanisms. Here, our aim was to identify founder mutations leading to subsequent boosts in mutation load. The overall mutation burden in 591 colorectal cancer tumors...

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Detalles Bibliográficos
Autores principales:	Pálinkás, Hajnalka Laura, Pongor, Lőrinc, Balajti, Máté, Nagy, Ádám, Nagy, Kinga, Békési, Angéla, Bianchini, Giampaolo, Vértessy, Beáta G., Győrffy, Balázs
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775830/ https://www.ncbi.nlm.nih.gov/pubmed/35054819 http://dx.doi.org/10.3390/ijms23020633

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