The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach

According to several animal and human studies, vitamin D appears to play a significant role in the development of diabetic nephropathy. However, the possible renoprotective effect of vitamin D and its influence on the reversal of already existing renal damage remains doubtful. At this moment, there...

Descripción completa

Detalles Bibliográficos
Autores principales: Delrue, Charlotte, Speeckaert, Reinhart, Delanghe, Joris R., Speeckaert, Marijn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775873/
https://www.ncbi.nlm.nih.gov/pubmed/35054991
http://dx.doi.org/10.3390/ijms23020807
_version_ 1784636692663107584
author Delrue, Charlotte
Speeckaert, Reinhart
Delanghe, Joris R.
Speeckaert, Marijn M.
author_facet Delrue, Charlotte
Speeckaert, Reinhart
Delanghe, Joris R.
Speeckaert, Marijn M.
author_sort Delrue, Charlotte
collection PubMed
description According to several animal and human studies, vitamin D appears to play a significant role in the development of diabetic nephropathy. However, the possible renoprotective effect of vitamin D and its influence on the reversal of already existing renal damage remains doubtful. At this moment, there are a few hypotheses concerning the underlying molecular and genetic mechanisms including the link between vitamin D and inflammation, oxidative stress, and extracellular matrix accumulation. The present review aims to investigate the potential role of vitamin D in the development of diabetic kidney disease from a translational approach.
format Online
Article
Text
id pubmed-8775873
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87758732022-01-21 The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach Delrue, Charlotte Speeckaert, Reinhart Delanghe, Joris R. Speeckaert, Marijn M. Int J Mol Sci Review According to several animal and human studies, vitamin D appears to play a significant role in the development of diabetic nephropathy. However, the possible renoprotective effect of vitamin D and its influence on the reversal of already existing renal damage remains doubtful. At this moment, there are a few hypotheses concerning the underlying molecular and genetic mechanisms including the link between vitamin D and inflammation, oxidative stress, and extracellular matrix accumulation. The present review aims to investigate the potential role of vitamin D in the development of diabetic kidney disease from a translational approach. MDPI 2022-01-12 /pmc/articles/PMC8775873/ /pubmed/35054991 http://dx.doi.org/10.3390/ijms23020807 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Delrue, Charlotte
Speeckaert, Reinhart
Delanghe, Joris R.
Speeckaert, Marijn M.
The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach
title The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach
title_full The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach
title_fullStr The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach
title_full_unstemmed The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach
title_short The Role of Vitamin D in Diabetic Nephropathy: A Translational Approach
title_sort role of vitamin d in diabetic nephropathy: a translational approach
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775873/
https://www.ncbi.nlm.nih.gov/pubmed/35054991
http://dx.doi.org/10.3390/ijms23020807
work_keys_str_mv AT delruecharlotte theroleofvitamindindiabeticnephropathyatranslationalapproach
AT speeckaertreinhart theroleofvitamindindiabeticnephropathyatranslationalapproach
AT delanghejorisr theroleofvitamindindiabeticnephropathyatranslationalapproach
AT speeckaertmarijnm theroleofvitamindindiabeticnephropathyatranslationalapproach
AT delruecharlotte roleofvitamindindiabeticnephropathyatranslationalapproach
AT speeckaertreinhart roleofvitamindindiabeticnephropathyatranslationalapproach
AT delanghejorisr roleofvitamindindiabeticnephropathyatranslationalapproach
AT speeckaertmarijnm roleofvitamindindiabeticnephropathyatranslationalapproach

Ejemplares similares