Cargando…

CD44, γ-H2AX, and p-ATM Expressions in Short-Term Ex Vivo Culture of Tumour Slices Predict the Treatment Response in Patients with Oral Squamous Cell Carcinoma

Squamous cell carcinoma is the most common type of head and neck cancer (HNSCC) with a disease-free survival at 3 years that does not exceed 30%. Biomarkers able to predict clinical outcomes are clearly needed. The purpose of this study was to investigate whether a short-term culture of tumour fragm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Philouze, Pierre, Gauthier, Arnaud, Lauret, Alexandra, Malesys, Céline, Muggiolu, Giovanna, Sauvaigo, Sylvie, Galmiche, Antoine, Ceruse, Philippe, Alphonse, Gersende, Wozny, Anne-Sophie, Rodriguez-Lafrasse, Claire
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775909/ https://www.ncbi.nlm.nih.gov/pubmed/35055060 http://dx.doi.org/10.3390/ijms23020877

Ejemplares similares

Circulating Tumor Cell Detection during Neoadjuvant Chemotherapy to Predict Early Response in Locally Advanced Oropharyngeal Cancers: A Prospective Pilot Study
por: Gauthier, Arnaud, et al.
Publicado: (2022)

Involvement of HIF-1α in the Detection, Signaling, and Repair of DNA Double-Strand Breaks after Photon and Carbon-Ion Irradiation
por: Wozny, Anne-Sophie, et al.
Publicado: (2021)

Impact of hypoxia on the double-strand break repair after photon and carbon ion irradiation of radioresistant HNSCC cells
por: Wozny, Anne-Sophie, et al.
Publicado: (2020)

Ceramide-Enriched Membrane Domains Contribute to Targeted and Nontargeted Effects of Radiation through Modulation of PI3K/AKT Signaling in HNSCC Cells
por: Ladjohounlou, Riad, et al.
Publicado: (2020)

ROS Production and Distribution: A New Paradigm to Explain the Differential Effects of X-ray and Carbon Ion Irradiation on Cancer Stem Cell Migration and Invasion
por: Wozny, Anne-Sophie, et al.
Publicado: (2019)

Differential pattern of HIF-1α expression in HNSCC cancer stem cells after carbon ion or photon irradiation: one molecular explanation of the oxygen effect
por: Wozny, Anne-Sophie, et al.
Publicado: (2017)

Dual “mAb” HER family blockade in head and neck cancer human cell lines combined with photon therapy
por: Guy, Jean-Baptiste, et al.
Publicado: (2017)

A rapid multiplex cell-free assay on biochip to evaluate functional aspects of double-strand break repair
por: Tatin, Xavier, et al.
Publicado: (2022)

Comparison of biophysical models with experimental data for three cell lines in response to irradiation with monoenergetic ions
por: Monini, Caterina, et al.
Publicado: (2019)

Influence of Dose Rate on the Cellular Response to Low- and High-LET Radiations
por: Wozny, Anne-Sophie, et al.
Publicado: (2016)

Corrigendum: Influence of Dose Rate on the Cellular Response to Low- and High-LET Radiations
por: Wozny, Anne-Sophie, et al.
Publicado: (2017)

Carbon ion irradiation withstands cancer stem cells' migration/invasion process in Head and Neck Squamous Cell Carcinoma (HNSCC)
por: Moncharmont, Coralie, et al.
Publicado: (2016)

Transient Alteration of Cellular Redox Buffering before Irradiation Triggers Apoptosis in Head and Neck Carcinoma Stem and Non-Stem Cells
por: Boivin, Anthony, et al.
Publicado: (2011)

The HINT1 tumor suppressor regulates both γ-H2AX and ATM in response to DNA damage
por: Li, Haiyang, et al.
Publicado: (2008)

Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK
por: Meyer, Barbara, et al.
Publicado: (2013)

Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC
por: Gilormini, Marion, et al.
Publicado: (2016)

The ‘stealth-bomber’ paradigm for deciphering the tumour response to carbon-ion irradiation
por: Wozny, Anne-Sophie, et al.
Publicado: (2023)

ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke
por: Tanaka, Toshiki, et al.
Publicado: (2007)

Abnormal Expression of DNA Double-Strand Breaks Related Genes, ATM and GammaH2AX, in Thyroid Carcinoma
por: Hu, Jin-lin, et al.
Publicado: (2015)

Genetic variations in ATM and H2AX loci contribute to risk of hematological abnormalities in individuals exposed to BTEX chemicals
por: Jafari Roshan, Samaneh, et al.
Publicado: (2022)

Glutathione Depletion and Carbon Ion Radiation Potentiate Clustered DNA Lesions, Cell Death and Prevent Chromosomal Changes in Cancer Cells Progeny
por: Hanot, Maïté, et al.
Publicado: (2012)

p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation
por: Alphonse, Gersende, et al.
Publicado: (2013)

AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation
por: Baritaud, M, et al.
Publicado: (2012)

ATM Localization and Heterochromatin Repair Depend on Direct Interaction of the 53BP1-BRCT(2) Domain with γH2AX
por: Baldock, Robert A., et al.
Publicado: (2015)

pATM and γH2AX are effective radiation biomarkers in assessing the radiosensitivity of (12)C(6+) in human tumor cells
por: Zhao, Jin, et al.
Publicado: (2017)

Using Microsoft Dynamics AX: the new dynamics 'AX 7'
por: Luszczak, Andreas
Publicado: (2016)

Telomerase inhibition improves tumor response to radiotherapy in a murine orthotopic model of human glioblastoma
por: Ferrandon, Sylvain, et al.
Publicado: (2015)

Formation of γH2AX and pATM Foci in Human Mesenchymal Stem Cells Exposed to Low Dose-Rate Gamma-Radiation
por: Ulyanenko, Stepan, et al.
Publicado: (2019)

Live-cell tracking of γ-H2AX kinetics reveals the distinct modes of ATM and DNA-PK in the immediate response to DNA damage
por: Trakarnphornsombat, Watanya, et al.
Publicado: (2023)

Heterogeneity of γH2AX Foci Increases in Ex Vivo Biopsies Relative to In Vivo Tumors
por: Rassamegevanon, Treewut, et al.
Publicado: (2018)

Low doses of X-rays induce prolonged and ATM-independent persistence of γH2AX foci in human gingival mesenchymal stem cells
por: Osipov, Andreyan N., et al.
Publicado: (2015)

A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells
por: Bakkenist, Christopher J., et al.
Publicado: (2015)

Porcine Enteric Coronavirus PEDV Induces the ROS-ATM and Caspase7-CAD-γH2AX Signaling Pathways to Foster Its Replication
por: Ming, Xin, et al.
Publicado: (2022)

The spindle gets the Axs
por: LeBrasseur, Nicole
Publicado: (2003)

Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome
por: Zhang, Haoyue, et al.
Publicado: (2016)

Examination of ex-vivo viability of human adipose tissue slice culture
por: Schopow, Nikolas, et al.
Publicado: (2020)

Harnessing the Utility of Ex Vivo Patient Prostate Tissue Slice Cultures
por: Perez, Lillian M., et al.
Publicado: (2022)

Photostability of 2D Organic-Inorganic Hybrid Perovskites
por: Wei, Yi, et al.
Publicado: (2014)

AxPcoords & parallel AxParafit: statistical co-phylogenetic analyses on thousands of taxa
por: Stamatakis, Alexandros, et al.
Publicado: (2007)

Performance of the AX-PET demonstrator
por: Beltrame, P, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_7qv1lq71pbjv50gt2og57aegeh