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Lipoprotein Profile in Populations from Regions of the Russian Federation: ESSE-RF Study

This study aimed to describe the dyslipidemia prevalence and pattern among adult populations from different regions (n = 13) of the Russian Federation (RF). Randomly selected samples (n = 22,258, aged 25–64) were studied according to the ESSE-RF protocol. Lipoprotein parameters were estimated by rou...

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Autores principales: Metelskaya, Victoria A., Shalnova, Svetlana A., Yarovaya, Elena B., Kutsenko, Vladimir A., Boytsov, Sergey A., Shlyakhto, Eugeny V., Drapkina, Oxana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775951/
https://www.ncbi.nlm.nih.gov/pubmed/35055754
http://dx.doi.org/10.3390/ijerph19020931
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author Metelskaya, Victoria A.
Shalnova, Svetlana A.
Yarovaya, Elena B.
Kutsenko, Vladimir A.
Boytsov, Sergey A.
Shlyakhto, Eugeny V.
Drapkina, Oxana M.
author_facet Metelskaya, Victoria A.
Shalnova, Svetlana A.
Yarovaya, Elena B.
Kutsenko, Vladimir A.
Boytsov, Sergey A.
Shlyakhto, Eugeny V.
Drapkina, Oxana M.
author_sort Metelskaya, Victoria A.
collection PubMed
description This study aimed to describe the dyslipidemia prevalence and pattern among adult populations from different regions (n = 13) of the Russian Federation (RF). Randomly selected samples (n = 22,258, aged 25–64) were studied according to the ESSE-RF protocol. Lipoprotein parameters were estimated by routine methods. Statistical analyses were performed using R software (v.3.5.1). The overall dyslipidemia prevalence was 76.1% (76.9/75.3% for men/women). In women, total cholesterol (TC) and low-density lipoprotein (LDL)-C levels gradually increased with age (from 4.72 to 5.93 and from 2.76 to 3.79 mmol/L, respectively); in men, they reached a maximum by 45–54 (5.55 and 3.55 mmol/L, respectively) and then decreased. No differences in high-density lipoprotein (HDL)-C in men of different ages were found, but slight decreases in HDL-C and apo AI were observed in women by 55–64 years. No pronounced associations between education and lipid levels in men were observed; higher-educated women showed significantly better lipoprotein profiles. Similar associations between lipids and income level were detected. Women from rural areas had higher TC and triglycerides than urban residents. Regardless of sex, rural residents had higher HDL-C and apo AI, and reduced apo B/apo AI. Conclusion: Information on the peculiarities of dyslipidemia prevalence and lipoprotein profile depending on sex, age, residential place, and socioeconomic status is useful for assessing the global ASCVD risk, and for risk modeling based on national data.
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spelling pubmed-87759512022-01-21 Lipoprotein Profile in Populations from Regions of the Russian Federation: ESSE-RF Study Metelskaya, Victoria A. Shalnova, Svetlana A. Yarovaya, Elena B. Kutsenko, Vladimir A. Boytsov, Sergey A. Shlyakhto, Eugeny V. Drapkina, Oxana M. Int J Environ Res Public Health Article This study aimed to describe the dyslipidemia prevalence and pattern among adult populations from different regions (n = 13) of the Russian Federation (RF). Randomly selected samples (n = 22,258, aged 25–64) were studied according to the ESSE-RF protocol. Lipoprotein parameters were estimated by routine methods. Statistical analyses were performed using R software (v.3.5.1). The overall dyslipidemia prevalence was 76.1% (76.9/75.3% for men/women). In women, total cholesterol (TC) and low-density lipoprotein (LDL)-C levels gradually increased with age (from 4.72 to 5.93 and from 2.76 to 3.79 mmol/L, respectively); in men, they reached a maximum by 45–54 (5.55 and 3.55 mmol/L, respectively) and then decreased. No differences in high-density lipoprotein (HDL)-C in men of different ages were found, but slight decreases in HDL-C and apo AI were observed in women by 55–64 years. No pronounced associations between education and lipid levels in men were observed; higher-educated women showed significantly better lipoprotein profiles. Similar associations between lipids and income level were detected. Women from rural areas had higher TC and triglycerides than urban residents. Regardless of sex, rural residents had higher HDL-C and apo AI, and reduced apo B/apo AI. Conclusion: Information on the peculiarities of dyslipidemia prevalence and lipoprotein profile depending on sex, age, residential place, and socioeconomic status is useful for assessing the global ASCVD risk, and for risk modeling based on national data. MDPI 2022-01-14 /pmc/articles/PMC8775951/ /pubmed/35055754 http://dx.doi.org/10.3390/ijerph19020931 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Metelskaya, Victoria A.
Shalnova, Svetlana A.
Yarovaya, Elena B.
Kutsenko, Vladimir A.
Boytsov, Sergey A.
Shlyakhto, Eugeny V.
Drapkina, Oxana M.
Lipoprotein Profile in Populations from Regions of the Russian Federation: ESSE-RF Study
title Lipoprotein Profile in Populations from Regions of the Russian Federation: ESSE-RF Study
title_full Lipoprotein Profile in Populations from Regions of the Russian Federation: ESSE-RF Study
title_fullStr Lipoprotein Profile in Populations from Regions of the Russian Federation: ESSE-RF Study
title_full_unstemmed Lipoprotein Profile in Populations from Regions of the Russian Federation: ESSE-RF Study
title_short Lipoprotein Profile in Populations from Regions of the Russian Federation: ESSE-RF Study
title_sort lipoprotein profile in populations from regions of the russian federation: esse-rf study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775951/
https://www.ncbi.nlm.nih.gov/pubmed/35055754
http://dx.doi.org/10.3390/ijerph19020931
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