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Two-Dimensional Interfacial Exchange Diffusion Has the Potential to Augment Spatiotemporal Precision of Ca(2+) Signaling

Nano-junctions between the endoplasmic reticulum and cytoplasmic surfaces of the plasma membrane and other organelles shape the spatiotemporal features of biological Ca(2+) signals. Herein, we propose that 2D Ca(2+) exchange diffusion on the negatively charged phospholipid surface lining nano-juncti...

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Autores principales: van Breemen, Cornelis, Fameli, Nicola, Groschner, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775956/
https://www.ncbi.nlm.nih.gov/pubmed/35055032
http://dx.doi.org/10.3390/ijms23020850
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author van Breemen, Cornelis
Fameli, Nicola
Groschner, Klaus
author_facet van Breemen, Cornelis
Fameli, Nicola
Groschner, Klaus
author_sort van Breemen, Cornelis
collection PubMed
description Nano-junctions between the endoplasmic reticulum and cytoplasmic surfaces of the plasma membrane and other organelles shape the spatiotemporal features of biological Ca(2+) signals. Herein, we propose that 2D Ca(2+) exchange diffusion on the negatively charged phospholipid surface lining nano-junctions participates in guiding Ca(2+) from its source (channel or carrier) to its target (transport protein or enzyme). Evidence provided by in vitro Ca(2+) flux experiments using an artificial phospholipid membrane is presented in support of the above proposed concept, and results from stochastic simulations of Ca(2+) trajectories within nano-junctions are discussed in order to substantiate its possible requirements. Finally, we analyze recent literature on Ca(2+) lipid interactions, which suggests that 2D interfacial Ca(2+) diffusion may represent an important mechanism of signal transduction in biological systems characterized by high phospholipid surface to aqueous volume ratios.
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spelling pubmed-87759562022-01-21 Two-Dimensional Interfacial Exchange Diffusion Has the Potential to Augment Spatiotemporal Precision of Ca(2+) Signaling van Breemen, Cornelis Fameli, Nicola Groschner, Klaus Int J Mol Sci Hypothesis Nano-junctions between the endoplasmic reticulum and cytoplasmic surfaces of the plasma membrane and other organelles shape the spatiotemporal features of biological Ca(2+) signals. Herein, we propose that 2D Ca(2+) exchange diffusion on the negatively charged phospholipid surface lining nano-junctions participates in guiding Ca(2+) from its source (channel or carrier) to its target (transport protein or enzyme). Evidence provided by in vitro Ca(2+) flux experiments using an artificial phospholipid membrane is presented in support of the above proposed concept, and results from stochastic simulations of Ca(2+) trajectories within nano-junctions are discussed in order to substantiate its possible requirements. Finally, we analyze recent literature on Ca(2+) lipid interactions, which suggests that 2D interfacial Ca(2+) diffusion may represent an important mechanism of signal transduction in biological systems characterized by high phospholipid surface to aqueous volume ratios. MDPI 2022-01-13 /pmc/articles/PMC8775956/ /pubmed/35055032 http://dx.doi.org/10.3390/ijms23020850 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Hypothesis
van Breemen, Cornelis
Fameli, Nicola
Groschner, Klaus
Two-Dimensional Interfacial Exchange Diffusion Has the Potential to Augment Spatiotemporal Precision of Ca(2+) Signaling
title Two-Dimensional Interfacial Exchange Diffusion Has the Potential to Augment Spatiotemporal Precision of Ca(2+) Signaling
title_full Two-Dimensional Interfacial Exchange Diffusion Has the Potential to Augment Spatiotemporal Precision of Ca(2+) Signaling
title_fullStr Two-Dimensional Interfacial Exchange Diffusion Has the Potential to Augment Spatiotemporal Precision of Ca(2+) Signaling
title_full_unstemmed Two-Dimensional Interfacial Exchange Diffusion Has the Potential to Augment Spatiotemporal Precision of Ca(2+) Signaling
title_short Two-Dimensional Interfacial Exchange Diffusion Has the Potential to Augment Spatiotemporal Precision of Ca(2+) Signaling
title_sort two-dimensional interfacial exchange diffusion has the potential to augment spatiotemporal precision of ca(2+) signaling
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775956/
https://www.ncbi.nlm.nih.gov/pubmed/35055032
http://dx.doi.org/10.3390/ijms23020850
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