Where Are We with RPE Replacement Therapy? A Translational Review from the Ophthalmologist Perspective

The retinal pigmented epithelium (RPE) plays a pivotal role in retinal homeostasis. It is therefore an interesting target to fill the unmet medical need of different retinal diseases, including age-related macular degeneration and Stargardt disease. RPE replacement therapy may use different cellular...

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Autores principales: Raimondi, Raffaele, Zollet, Piero, De Rosa, Francesco Paolo, Tsoutsanis, Panagiotis, Stravalaci, Matteo, Paulis, Marianna, Inforzato, Antonio, Romano, Mario R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775975/
https://www.ncbi.nlm.nih.gov/pubmed/35054869
http://dx.doi.org/10.3390/ijms23020682
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author Raimondi, Raffaele
Zollet, Piero
De Rosa, Francesco Paolo
Tsoutsanis, Panagiotis
Stravalaci, Matteo
Paulis, Marianna
Inforzato, Antonio
Romano, Mario R.
author_facet Raimondi, Raffaele
Zollet, Piero
De Rosa, Francesco Paolo
Tsoutsanis, Panagiotis
Stravalaci, Matteo
Paulis, Marianna
Inforzato, Antonio
Romano, Mario R.
author_sort Raimondi, Raffaele
collection PubMed
description The retinal pigmented epithelium (RPE) plays a pivotal role in retinal homeostasis. It is therefore an interesting target to fill the unmet medical need of different retinal diseases, including age-related macular degeneration and Stargardt disease. RPE replacement therapy may use different cellular sources: induced pluripotent stem cells or embryonic stem cells. Cells can be transferred as suspension on a patch with different surgical approaches. Results are promising although based on very limited samples. In this review, we summarize the current progress of RPE replacement and provide a comparative assessment of different published approaches which may become standard of care in the future.
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spelling pubmed-87759752022-01-21 Where Are We with RPE Replacement Therapy? A Translational Review from the Ophthalmologist Perspective Raimondi, Raffaele Zollet, Piero De Rosa, Francesco Paolo Tsoutsanis, Panagiotis Stravalaci, Matteo Paulis, Marianna Inforzato, Antonio Romano, Mario R. Int J Mol Sci Review The retinal pigmented epithelium (RPE) plays a pivotal role in retinal homeostasis. It is therefore an interesting target to fill the unmet medical need of different retinal diseases, including age-related macular degeneration and Stargardt disease. RPE replacement therapy may use different cellular sources: induced pluripotent stem cells or embryonic stem cells. Cells can be transferred as suspension on a patch with different surgical approaches. Results are promising although based on very limited samples. In this review, we summarize the current progress of RPE replacement and provide a comparative assessment of different published approaches which may become standard of care in the future. MDPI 2022-01-08 /pmc/articles/PMC8775975/ /pubmed/35054869 http://dx.doi.org/10.3390/ijms23020682 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Raimondi, Raffaele
Zollet, Piero
De Rosa, Francesco Paolo
Tsoutsanis, Panagiotis
Stravalaci, Matteo
Paulis, Marianna
Inforzato, Antonio
Romano, Mario R.
Where Are We with RPE Replacement Therapy? A Translational Review from the Ophthalmologist Perspective
title Where Are We with RPE Replacement Therapy? A Translational Review from the Ophthalmologist Perspective
title_full Where Are We with RPE Replacement Therapy? A Translational Review from the Ophthalmologist Perspective
title_fullStr Where Are We with RPE Replacement Therapy? A Translational Review from the Ophthalmologist Perspective
title_full_unstemmed Where Are We with RPE Replacement Therapy? A Translational Review from the Ophthalmologist Perspective
title_short Where Are We with RPE Replacement Therapy? A Translational Review from the Ophthalmologist Perspective
title_sort where are we with rpe replacement therapy? a translational review from the ophthalmologist perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8775975/
https://www.ncbi.nlm.nih.gov/pubmed/35054869
http://dx.doi.org/10.3390/ijms23020682
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