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IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance

Isoprenoids are vital to all organisms in supporting core functions of life, like respiration and membrane stability.(1) IspH, an enzyme in the methyl erythritol phosphate pathway of isoprenoid synthesis, is essential to gram-negative bacteria, mycobacteria and apicomplexans.(2,3) The IspH substrate...

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Detalles Bibliográficos
Autores principales:	Singh, Kumar Sachin, Sharma, Rishabh, Reddy, Poli Adi Narayana, Vonteddu, Prashanthi, Good, Madeline, Sundarrajan, Anjana, Choi, Hyeree, Muthumani, Kar, Kossenkov, Andrew, Goldman, Aaron R., Tang, Hsin-Yao, Totrov, Maxim, Cassel, Joel, Murphy, Maureen E., Somasundaram, Rajasekharan, Herlyn, Meenhard, Salvino, Joseph M., Dotiwala, Farokh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776033/ https://www.ncbi.nlm.nih.gov/pubmed/33361818 http://dx.doi.org/10.1038/s41586-020-03074-x

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