Cargando…

XRCC4 and MRE11 Roles and Transcriptional Response to Repair of TALEN-Induced Double-Strand DNA Breaks

Double-strand breaks (DSB) are one of the most lethal forms of DNA damage that, if left unrepaired, can lead to genomic instability, cellular transformation, and cell death. In this work, we examined how repair of transcription activator-like effector nuclease (TALEN)-induced DNA damage was altered...

Descripción completa

Detalles Bibliográficos
Autores principales:	Benjamin, Ronald, Banerjee, Atoshi, Wu, Xiaogang, Geurink, Corey, Buczek, Lindsay, Eames, Danielle, Trimidal, Sara G., Pluth, Janice M., Schiller, Martin R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776116/ https://www.ncbi.nlm.nih.gov/pubmed/35054780 http://dx.doi.org/10.3390/ijms23020593

Ejemplares similares

Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11
por: Di Virgilio, Michela, et al.
Publicado: (2005)

Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1
por: Garcia, Valerie, et al.
Publicado: (2011)

Analysis of MRE11's function in the 5′→3′ processing of DNA double-strand breaks
por: Liao, Shuren, et al.
Publicado: (2012)

Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks
por: Muraki, Keiko, et al.
Publicado: (2015)

Mre11-Rad50 oligomerization promotes DNA double-strand break repair
por: Kissling, Vera M., et al.
Publicado: (2022)

Effects of mitoTALENs-Directed Double-Strand Breaks on Plant Mitochondrial Genomes
por: Arimura, Shin-ichi
Publicado: (2021)

Mre11–Rad50–Xrs2 and Sae2 promote 5’ strand resection of DNA double-strand breaks
por: Nicolette, Matthew L., et al.
Publicado: (2010)

Mre11 regulates CtIP–dependent double strand break repair by interaction with CDK2
por: Buis, Jeffrey, et al.
Publicado: (2012)

XRCC1 is required for DNA single-strand break repair in human cells
por: Brem, Reto, et al.
Publicado: (2005)

DNA Double Strand Break Repair in Mitosis Is Suppressed by Phosphorylation of XRCC4
por: Lees-Miller, Susan P.
Publicado: (2014)

The role of the Mre11–Rad50–Nbs1 complex in double-strand break repair—facts and myths
por: Takeda, Shunichi, et al.
Publicado: (2016)

The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair
por: Liao, Shuren, et al.
Publicado: (2016)

Nej1 Interacts with Mre11 to Regulate Tethering and Dna2 Binding at DNA Double-Strand Breaks
por: Mojumdar, Aditya, et al.
Publicado: (2019)

GigaAssay – An adaptable high-throughput saturation mutagenesis assay platform
por: Benjamin, Ronald, et al.
Publicado: (2022)

Data supporting a saturation mutagenesis assay for Tat-driven transcription with the GigaAssay
por: Benjamin, Ronald, et al.
Publicado: (2022)

MRE11 Function in Response to Topoisomerase Poisons Is Independent of its Function in Double-Strand Break Repair in Saccharomyces cerevisiae
por: Hamilton, Nicolle K., et al.
Publicado: (2010)

Ctp1-dependent clipping and resection of DNA double-strand breaks by Mre11 endonuclease complex are not genetically separable
por: Jensen, Kristi L., et al.
Publicado: (2016)

TRIP13 Participates in Immediate-Early Sensing of DNA Strand Breaks and ATM Signaling Amplification through MRE11
por: Jeong, Hyeongsun, et al.
Publicado: (2022)

Targeted Modification of Gene Function Exploiting Homology-Directed Repair of TALEN-Mediated Double-Strand Breaks in Barley
por: Budhagatapalli, Nagaveni, et al.
Publicado: (2015)

XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair
por: Hammel, Michal, et al.
Publicado: (2011)

Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers
por: Alblihy, Adel, et al.
Publicado: (2022)

APTX acts in DNA double-strand break repair in a manner distinct from XRCC4
por: Imamura, Rikiya, et al.
Publicado: (2023)

Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair
por: Limbo, Oliver, et al.
Publicado: (2012)

In silico characterization and Molecular modeling of double-strand break repair protein MRE11 from Phoenix dactylifera v deglet nour
por: Rekik, Imen, et al.
Publicado: (2015)

Bcl2 inhibits recruitment of Mre11 complex to DNA double-strand breaks in response to high-linear energy transfer radiation
por: Xie, Maohua, et al.
Publicado: (2015)

MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex
por: Lee, Kyung Yong, et al.
Publicado: (2015)

Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repair
por: Campalans, Anna, et al.
Publicado: (2013)

In cellulo phosphorylation of DNA double-strand break repair protein XRCC4 on Ser260 by DNA-PK
por: Amiri Moghani, Ali Reza, et al.
Publicado: (2018)

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks
por: Langerak, Petra, et al.
Publicado: (2011)

MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends
por: Sharma, Sheetal, et al.
Publicado: (2021)

Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF
por: Jayaram, Sumithra, et al.
Publicado: (2008)

Coincident Resection at Both Ends of Random, γ–Induced Double-Strand Breaks Requires MRX (MRN), Sae2 (Ctp1), and Mre11-Nuclease
por: Westmoreland, James W., et al.
Publicado: (2013)

Deubiquitinase USP2 stabilizes the MRE11–RAD50–NBS1 complex at DNA double-strand break sites by counteracting the ubiquitination of NBS1
por: Kim, Hyunsup, et al.
Publicado: (2022)

Transcription-associated recombination is independent of XRCC2 and mechanistically separate from homology-directed DNA double-strand break repair
por: Savolainen, Linda, et al.
Publicado: (2009)

Functional Interplay between the 53BP1-Ortholog Rad9 and the Mre11 Complex Regulates Resection, End-Tethering and Repair of a Double-Strand Break
por: Ferrari, Matteo, et al.
Publicado: (2015)

Topological Analysis of γH2AX and MRE11 Clusters Detected by Localization Microscopy during X-ray-Induced DNA Double-Strand Break Repair
por: Hahn, Hannes, et al.
Publicado: (2021)

Precise Gene Modification Mediated by TALEN and Single-Stranded Oligodeoxynucleotides in Human Cells
por: Wang, Xiaoling, et al.
Publicado: (2014)

APE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instability
por: Sossou, Marguerite, et al.
Publicado: (2005)

Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly(ADP-ribose)
por: Wei, Leizhen, et al.
Publicado: (2013)

Susceptibility to Breast Cancer and Intron 3 Ins/Del Genetic Polymorphism of DNA Double-Strand Break Repair Gene XRCC4
por: Saadat, Mostafa, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_n7ft2690kbssvcr6eigsp0d1ok