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Carotid Artery Plaque Progression: Proposal of a New Predictive Score and Role of Carotid Intima-Media Thickness

Background: We aimed to investigate if the carotid intima-media thickness (IMT) at baseline and the HAD(2)S score, composed of the sum of single risk factors (hypertension, age ≥ 75 years, diabetes, dyslipidemia, smoking), were predictive of plaque progression. Methods: We performed a retrospective...

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Autores principales: Brunelli, Nicoletta, Altamura, Claudia, Costa, Carmelina Maria, Altavilla, Riccardo, Palazzo, Paola, Maggio, Paola, Marcosano, Marilena, Vernieri, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776120/
https://www.ncbi.nlm.nih.gov/pubmed/35055580
http://dx.doi.org/10.3390/ijerph19020758
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author Brunelli, Nicoletta
Altamura, Claudia
Costa, Carmelina Maria
Altavilla, Riccardo
Palazzo, Paola
Maggio, Paola
Marcosano, Marilena
Vernieri, Fabrizio
author_facet Brunelli, Nicoletta
Altamura, Claudia
Costa, Carmelina Maria
Altavilla, Riccardo
Palazzo, Paola
Maggio, Paola
Marcosano, Marilena
Vernieri, Fabrizio
author_sort Brunelli, Nicoletta
collection PubMed
description Background: We aimed to investigate if the carotid intima-media thickness (IMT) at baseline and the HAD(2)S score, composed of the sum of single risk factors (hypertension, age ≥ 75 years, diabetes, dyslipidemia, smoking), were predictive of plaque progression. Methods: We performed a retrospective analysis on real-life prospectively collected data from patients with any detectable carotid plaque at follow up. The plaque score, calculated at baseline (T0) and at a median follow up of 36.6 months (IQR 39.6–34.3) (T3), was defined as 0: no plaque or stenosis < 30%; 1: stenosis in the range 30–49%; 2: in the range 50–69%; 3: in the range 70–99% and 4: occlusion. Carotid IMT was measured at T0 and T3; HAD(2)S score was calculated at baseline. Results: We included 340 patients with a mean age of 69.9 (9.1) years and 25.3% subjects had plaque progression. Individuals with progression had a median HAD(2)S score of 3 (1) while those without progression had 2 (1). Patients with progression had a mean baseline IMT of 0.86 (0.17) while those without progression had 0.77 (0.18) (p < 0.0001). A correlation between progression and baseline IMT was found (p = 0.002). Conclusion: Baseline IMT could be considered a predictor of progression. Patients with progression had an HAD(2)S score higher than those without evolution.
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spelling pubmed-87761202022-01-21 Carotid Artery Plaque Progression: Proposal of a New Predictive Score and Role of Carotid Intima-Media Thickness Brunelli, Nicoletta Altamura, Claudia Costa, Carmelina Maria Altavilla, Riccardo Palazzo, Paola Maggio, Paola Marcosano, Marilena Vernieri, Fabrizio Int J Environ Res Public Health Article Background: We aimed to investigate if the carotid intima-media thickness (IMT) at baseline and the HAD(2)S score, composed of the sum of single risk factors (hypertension, age ≥ 75 years, diabetes, dyslipidemia, smoking), were predictive of plaque progression. Methods: We performed a retrospective analysis on real-life prospectively collected data from patients with any detectable carotid plaque at follow up. The plaque score, calculated at baseline (T0) and at a median follow up of 36.6 months (IQR 39.6–34.3) (T3), was defined as 0: no plaque or stenosis < 30%; 1: stenosis in the range 30–49%; 2: in the range 50–69%; 3: in the range 70–99% and 4: occlusion. Carotid IMT was measured at T0 and T3; HAD(2)S score was calculated at baseline. Results: We included 340 patients with a mean age of 69.9 (9.1) years and 25.3% subjects had plaque progression. Individuals with progression had a median HAD(2)S score of 3 (1) while those without progression had 2 (1). Patients with progression had a mean baseline IMT of 0.86 (0.17) while those without progression had 0.77 (0.18) (p < 0.0001). A correlation between progression and baseline IMT was found (p = 0.002). Conclusion: Baseline IMT could be considered a predictor of progression. Patients with progression had an HAD(2)S score higher than those without evolution. MDPI 2022-01-11 /pmc/articles/PMC8776120/ /pubmed/35055580 http://dx.doi.org/10.3390/ijerph19020758 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Brunelli, Nicoletta
Altamura, Claudia
Costa, Carmelina Maria
Altavilla, Riccardo
Palazzo, Paola
Maggio, Paola
Marcosano, Marilena
Vernieri, Fabrizio
Carotid Artery Plaque Progression: Proposal of a New Predictive Score and Role of Carotid Intima-Media Thickness
title Carotid Artery Plaque Progression: Proposal of a New Predictive Score and Role of Carotid Intima-Media Thickness
title_full Carotid Artery Plaque Progression: Proposal of a New Predictive Score and Role of Carotid Intima-Media Thickness
title_fullStr Carotid Artery Plaque Progression: Proposal of a New Predictive Score and Role of Carotid Intima-Media Thickness
title_full_unstemmed Carotid Artery Plaque Progression: Proposal of a New Predictive Score and Role of Carotid Intima-Media Thickness
title_short Carotid Artery Plaque Progression: Proposal of a New Predictive Score and Role of Carotid Intima-Media Thickness
title_sort carotid artery plaque progression: proposal of a new predictive score and role of carotid intima-media thickness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776120/
https://www.ncbi.nlm.nih.gov/pubmed/35055580
http://dx.doi.org/10.3390/ijerph19020758
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