Computer Modeling Explains the Structural Reasons for the Difference in Reactivity of Amine Transaminases Regarding Prochiral Methylketones

Amine transaminases (ATAs) are pyridoxal-5′-phosphate (PLP)-dependent enzymes that catalyze the transfer of an amino group from an amino donor to an aldehyde and/or ketone. In the past decade, the enzymatic reductive amination of prochiral ketones catalyzed by ATAs has attracted the attention of res...

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Detalles Bibliográficos
Autores principales: Teixeira, Iris S., Farias, André B., Horta, Bruno A. C., Milagre, Humberto M. S., de Souza, Rodrigo O. M. A., Bornscheuer, Uwe T., Milagre, Cintia D. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776209/
https://www.ncbi.nlm.nih.gov/pubmed/35054965
http://dx.doi.org/10.3390/ijms23020777

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