ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

Despite tremendous progress in the understanding of COVID-19, mechanistic insight into immunological, disease-driving factors remains limited. We generated maVie16, a mouse-adapted SARS-CoV-2, by serial passaging of a human isolate. In silico modeling revealed how only three Spike mutations of maVie...

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Detalles Bibliográficos
Autores principales: Gawish, Riem, Starkl, Philipp, Pimenov, Lisabeth, Hladik, Anastasiya, Lakovits, Karin, Oberndorfer, Felicitas, Cronin, Shane JF, Ohradanova-Repic, Anna, Wirnsberger, Gerald, Agerer, Benedikt, Endler, Lukas, Capraz, Tümay, Perthold, Jan W, Cikes, Domagoj, Koglgruber, Rubina, Hagelkruys, Astrid, Montserrat, Nuria, Mirazimi, Ali, Boon, Louis, Stockinger, Hannes, Bergthaler, Andreas, Oostenbrink, Chris, Penninger, Josef M, Knapp, Sylvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776253/
https://www.ncbi.nlm.nih.gov/pubmed/35023830
http://dx.doi.org/10.7554/eLife.74623

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