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Decoupling of functional and structural language networks in temporal lobe epilepsy
OBJECTIVE: To identify functional and structural alterations in language networks of people with temporal lobe epilepsy (TLE), who frequently present with naming and word‐finding difficulties. METHODS: Fifty‐five patients with unilateral TLE (29 left) and 16 controls were studied with auditory and p...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776336/ https://www.ncbi.nlm.nih.gov/pubmed/34642939 http://dx.doi.org/10.1111/epi.17098 |
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author | Trimmel, Karin Vos, Sjoerd B. Caciagli, Lorenzo Xiao, Fenglai van Graan, Louis A. Winston, Gavin P. Koepp, Matthias J. Thompson, Pamela J. Duncan, John S. |
author_facet | Trimmel, Karin Vos, Sjoerd B. Caciagli, Lorenzo Xiao, Fenglai van Graan, Louis A. Winston, Gavin P. Koepp, Matthias J. Thompson, Pamela J. Duncan, John S. |
author_sort | Trimmel, Karin |
collection | PubMed |
description | OBJECTIVE: To identify functional and structural alterations in language networks of people with temporal lobe epilepsy (TLE), who frequently present with naming and word‐finding difficulties. METHODS: Fifty‐five patients with unilateral TLE (29 left) and 16 controls were studied with auditory and picture naming functional magnetic resonance imaging (fMRI) tasks. Activation maxima in the left posterobasal temporal lobe were used as seed regions for whole‐brain functional connectivity analyses (psychophysiological interaction). White matter language pathways were investigated using diffusion tensor imaging and neurite orientation dispersion and density imaging metrics extracted along fiber bundles starting from fMRI‐guided seeds. Regression analyses were performed to investigate the correlation of functional connectivity with diffusion MRI metrics. RESULTS: In the whole group of patients and controls, weaker functional connectivity from the left posterobasal temporal lobe (1) to the bilateral anterior temporal lobe, precentral gyrus, and lingual gyrus during auditory naming and (2) to the bilateral occipital cortex and right fusiform gyrus during picture naming was associated with decreased neurite orientation dispersion and higher free water fraction of white matter tracts. Compared to controls, TLE patients exhibited fewer structural connections and an impaired coupling of functional and structural metrics. SIGNIFICANCE: TLE is associated with an impairment and decoupling of functional and structural language networks. White matter damage, as evidenced by diffusion abnormalities, may contribute to impaired functional connectivity and language dysfunction in TLE. |
format | Online Article Text |
id | pubmed-8776336 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87763362022-01-24 Decoupling of functional and structural language networks in temporal lobe epilepsy Trimmel, Karin Vos, Sjoerd B. Caciagli, Lorenzo Xiao, Fenglai van Graan, Louis A. Winston, Gavin P. Koepp, Matthias J. Thompson, Pamela J. Duncan, John S. Epilepsia Full‐length Original Research OBJECTIVE: To identify functional and structural alterations in language networks of people with temporal lobe epilepsy (TLE), who frequently present with naming and word‐finding difficulties. METHODS: Fifty‐five patients with unilateral TLE (29 left) and 16 controls were studied with auditory and picture naming functional magnetic resonance imaging (fMRI) tasks. Activation maxima in the left posterobasal temporal lobe were used as seed regions for whole‐brain functional connectivity analyses (psychophysiological interaction). White matter language pathways were investigated using diffusion tensor imaging and neurite orientation dispersion and density imaging metrics extracted along fiber bundles starting from fMRI‐guided seeds. Regression analyses were performed to investigate the correlation of functional connectivity with diffusion MRI metrics. RESULTS: In the whole group of patients and controls, weaker functional connectivity from the left posterobasal temporal lobe (1) to the bilateral anterior temporal lobe, precentral gyrus, and lingual gyrus during auditory naming and (2) to the bilateral occipital cortex and right fusiform gyrus during picture naming was associated with decreased neurite orientation dispersion and higher free water fraction of white matter tracts. Compared to controls, TLE patients exhibited fewer structural connections and an impaired coupling of functional and structural metrics. SIGNIFICANCE: TLE is associated with an impairment and decoupling of functional and structural language networks. White matter damage, as evidenced by diffusion abnormalities, may contribute to impaired functional connectivity and language dysfunction in TLE. John Wiley and Sons Inc. 2021-10-12 2021-12 /pmc/articles/PMC8776336/ /pubmed/34642939 http://dx.doi.org/10.1111/epi.17098 Text en © 2021 The Authors. Epilepsia published by Wiley Periodicals LLC on behalf of International League Against Epilepsy https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Full‐length Original Research Trimmel, Karin Vos, Sjoerd B. Caciagli, Lorenzo Xiao, Fenglai van Graan, Louis A. Winston, Gavin P. Koepp, Matthias J. Thompson, Pamela J. Duncan, John S. Decoupling of functional and structural language networks in temporal lobe epilepsy |
title | Decoupling of functional and structural language networks in temporal lobe epilepsy |
title_full | Decoupling of functional and structural language networks in temporal lobe epilepsy |
title_fullStr | Decoupling of functional and structural language networks in temporal lobe epilepsy |
title_full_unstemmed | Decoupling of functional and structural language networks in temporal lobe epilepsy |
title_short | Decoupling of functional and structural language networks in temporal lobe epilepsy |
title_sort | decoupling of functional and structural language networks in temporal lobe epilepsy |
topic | Full‐length Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776336/ https://www.ncbi.nlm.nih.gov/pubmed/34642939 http://dx.doi.org/10.1111/epi.17098 |
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