Cargando…

Network Pharmacology Prediction: The Possible Mechanisms of Cinobufotalin against Osteosarcoma

OBJECTIVE: To explore the active compounds and targets of cinobufotalin (huachansu) compared with the osteosarcoma genes to obtain the potential therapeutic targets and pharmacological mechanisms of action of cinobufotalin on osteosarcoma through network pharmacology. METHODS: The composition of cin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Riyu, Guan, Zeyi, Zhong, Xianxing, Zhang, Wenzheng, Zhang, Ya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776428/ https://www.ncbi.nlm.nih.gov/pubmed/35069780 http://dx.doi.org/10.1155/2022/3197402

Ejemplares similares

Network Pharmacology Study on the Pharmacological Mechanism of Cinobufotalin Injection against Lung Cancer
por: Mao, Yun, et al.
Publicado: (2020)

The Potential Mechanisms of Cinobufotalin Treating Colon Adenocarcinoma by Network Pharmacology
por: Wang, Jiyan, et al.
Publicado: (2022)

Combined Treatment of Cinobufotalin and Gefitinib Exhibits Potent Efficacy against Lung Cancer
por: Han, Youxi, et al.
Publicado: (2021)

Network pharmacology and molecular docking reveal the mechanism of Angelica dahurica against Osteosarcoma
por: Zhang, Yafang, et al.
Publicado: (2022)

Network pharmacology, molecular docking and bioinformatics reveal the mechanism of Tripterygii Wilfordii against Osteosarcoma
por: Zhang, Yafang, et al.
Publicado: (2022)

Elucidation of the Differences in Cinobufotalin’s Pharmacokinetics Between Normal and Diethylnitrosamine-Injured Rats: The Role of P-Glycoprotein
por: Zhang, Xiaojing, et al.
Publicado: (2019)

Differentially expressed gene profile and relevant pathways of the traditional Chinese medicine cinobufotalin on MCF-7 breast cancer cells
por: Li, Jie, et al.
Publicado: (2019)

Network pharmacology-based research on the effect of angelicin on osteosarcoma and the underlying mechanism
por: Zhang, Yafang, et al.
Publicado: (2023)

Cinobufotalin as an effective adjuvant therapy for advanced gastric cancer: a meta-analysis of randomized controlled trials
por: Sun, Huiling, et al.
Publicado: (2019)

Network pharmacology-based research on the effect of Scutellaria baicalensis on osteosarcoma and the underlying mechanism
por: Zhang, Lijuan, et al.
Publicado: (2023)

Network pharmacology-based pharmacological mechanism prediction on Eucommia ulmoides against rheumatoid arthritis
por: Ying, Yonggan, et al.
Publicado: (2022)

Network Pharmacology-Based Prediction of Catalpol and Mechanisms against Stroke
por: Wang, Jinghui, et al.
Publicado: (2021)

The Effectiveness and Safety of Cinobufotalin Injection as an Adjunctive Treatment for Lung Cancer: A Meta-Analysis of Randomized Controlled Trials
por: Li, Lin-Lu, et al.
Publicado: (2021)

Cinobufotalin injection combined with chemotherapy for the treatment of advanced NSCLC in China: A PRISMA-compliant meta-analysis of 29 randomized controlled trials
por: Zhang, Fan, et al.
Publicado: (2019)

Combination of TPF regimen and cinobufotalin inhibits proliferation and induces apoptosis in human hypopharyngeal and laryngeal squamous cell carcinoma cells
por: Shen, Xixi, et al.
Publicado: (2018)

Chemical compound cinobufotalin potently induces FOXO1-stimulated cisplatin sensitivity by antagonizing its binding partner MYH9
por: Li, YongHao, et al.
Publicado: (2019)

Network pharmacology-based pharmacological mechanism prediction of Lycii Fructus against postmenopausal osteoporosis
por: Wang, Jianbo, et al.
Publicado: (2023)

Anti-cancer targets and molecular mechanisms of formononetin in treating osteosarcoma based on network pharmacology
por: Chen, Lizhi, et al.
Publicado: (2023)

Phosphoproteomics reveals that cinobufotalin promotes intrahepatic cholangiocarcinoma cell apoptosis by activating the ATM/CHK2/p53 signaling pathway
por: Xia, Zhili, et al.
Publicado: (2022)

Molecular mechanisms of osteosarcoma metastasis and possible treatment opportunities
por: Du, Xinhui, et al.
Publicado: (2023)

Network Pharmacology-Based Prediction of Active Ingredients and Mechanisms of Lamiophlomis rotata (Benth.) Kudo Against Rheumatoid Arthritis
por: Jiang, Yunbin, et al.
Publicado: (2019)

Use of network pharmacology and molecular docking to explore the mechanism of action of curcuma in the treatment of osteosarcoma
por: Hu, Minhua, et al.
Publicado: (2023)

Network pharmacology and experimental verification-based strategy for exploring the mechanisms of luteolin in the treatment of osteosarcoma
por: Huang, Renxuan, et al.
Publicado: (2023)

Network Pharmacology-Based Strategy to Identify the Pharmacological Mechanisms of Pulsatilla Decoction against Crohn’s Disease
por: Liu, Jinguo, et al.
Publicado: (2022)

Network pharmacology combined with molecular docking and experimental validation to reveal the pharmacological mechanism of naringin against renal fibrosis
por: Zhong, Yanan, et al.
Publicado: (2023)

Network Pharmacology-Based Strategy to Reveal the Mechanism of Cassiae Semen against Cataracts
por: Zhong, Ying, et al.
Publicado: (2022)

Mechanism of Tetrandrine Against Endometrial Cancer Based on Network Pharmacology
por: Shang, Wenqian, et al.
Publicado: (2021)

Network Pharmacology-Based Study on the Mechanism of Gegen Qinlian Decoction against Colorectal Cancer
por: Fan, Qiaowei, et al.
Publicado: (2020)

Integrated Network Pharmacology Analysis and Experimental Validation to Investigate the Mechanism of Zhi-Zi-Hou-Po Decoction in Depression
por: Bai, Yongtao, et al.
Publicado: (2021)

Mechanisms of dihydromyricetin against hepatocellular carcinoma elucidated by network pharmacology combined with experimental validation
por: Zhang, Shuo, et al.
Publicado: (2023)

Network Pharmacology and Molecular Docking-Based Prediction of the Mechanism of Qianghuo Shengshi Decoction against Rheumatoid Arthritis
por: Zeng, Zhihao, et al.
Publicado: (2021)

Integrating network pharmacology and experimental verification to explore the pharmacological mechanisms of asparagus against polycystic ovary syndrome
por: Xing, Jinshan, et al.
Publicado: (2023)

Network Pharmacology-Based Pharmacological Mechanism of the Chinese Medicine Rhizoma drynariae Against Osteoporosis
por: Gan, Donghao, et al.
Publicado: (2019)

ENKUR expression induced by chemically synthesized cinobufotalin suppresses malignant activities of hepatocellular carcinoma by modulating β-catenin/c-Jun/MYH9/USP7/c-Myc axis
por: Hou, Rentao, et al.
Publicado: (2022)

Pharmacological Mechanisms of Tinglizi against Chronic Heart Failure Determined by Network Pharmacology and Molecular Docking
por: Luo, Liangtao, et al.
Publicado: (2022)

Network Pharmacology-Based Prediction and Verification of the Targets and Mechanism for Panax Notoginseng Saponins against Coronary Heart Disease
por: Dong, Yan, et al.
Publicado: (2019)

Network Pharmacology Identifies the Mechanisms of Action of TaohongSiwu Decoction Against Essential Hypertension
por: Liu, Tian-hao, et al.
Publicado: (2020)

Network Pharmacology Prediction and Molecular Docking-Based Strategy to Discover the Potential Pharmacological Mechanism of Huai Hua San Against Ulcerative Colitis
por: Liu, Jiaqin, et al.
Publicado: (2021)

Network Pharmacology Prediction and Pharmacological Verification Mechanism of Yeju Jiangya Decoction on Hypertension
por: Wang, Ting, et al.
Publicado: (2021)

Integration of Network Pharmacology and Experimental Validation to Explore the Pharmacological Mechanisms of Zhuanggu Busui Formula Against Osteoporosis
por: Zhang, Huihao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hjscjm2ppp5732tsdg6v5sge7n