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Advanced Glycation End Products Induce Atherosclerosis via RAGE/TLR4 Signaling Mediated-M1 Macrophage Polarization-Dependent Vascular Smooth Muscle Cell Phenotypic Conversion

OBJECTIVE: The objective of this study was to investigate the involved mechanisms of advanced glycation end product- (AGE-) exacerbated atherosclerosis (AS). METHODS: Toll-like receptor 4 (TLR4) inhibitor was administrated to type 2 diabetes mellitus (T2DM) AS rats. Atherosclerotic plaque, M1 macrop...

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Detalles Bibliográficos
Autores principales:	Xing, Yujie, Pan, Shuo, Zhu, Ling, Cui, Qianwei, Tang, Zhiguo, Liu, Zhongwei, Liu, Fuqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776434/ https://www.ncbi.nlm.nih.gov/pubmed/35069982 http://dx.doi.org/10.1155/2022/9763377

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