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One in a Million: A Case Report of Stiff Person Syndrome
Stiff person syndrome (SPS) is a rare autoimmune disease caused by lack of inhibition to excitatory neurotransmitters in the central nervous system (CNS) leading to inappropriate motor unit firing. The pathophysiology is incompletely understood; however, high titers of antiglutamic acid decarboxylas...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776484/ https://www.ncbi.nlm.nih.gov/pubmed/35070465 http://dx.doi.org/10.1155/2022/7741545 |
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author | Yadav, Ruchi Abrol, Neeraj Terebelo, Sima |
author_facet | Yadav, Ruchi Abrol, Neeraj Terebelo, Sima |
author_sort | Yadav, Ruchi |
collection | PubMed |
description | Stiff person syndrome (SPS) is a rare autoimmune disease caused by lack of inhibition to excitatory neurotransmitters in the central nervous system (CNS) leading to inappropriate motor unit firing. The pathophysiology is incompletely understood; however, high titers of antiglutamic acid decarboxylase antibody (anti-GAD Ab) are strongly associated with this disease. We present a 50-year-old woman with a history of ongoing gait and balance issues for 5 years with multiple negative workups. She recently had an acute exacerbation which left her bedbound, unable to move her legs or turn from side to side. After a negative workup at an outside hospital, the patient was discharged to a subacute rehabilitation facility. She then presented to our institution due to worsening of her condition and was ultimately diagnosed with SPS which was successfully treated. We review the case presentation and treatment options in the context of a severe disabling disease presentation. |
format | Online Article Text |
id | pubmed-8776484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-87764842022-01-21 One in a Million: A Case Report of Stiff Person Syndrome Yadav, Ruchi Abrol, Neeraj Terebelo, Sima Case Rep Rheumatol Case Report Stiff person syndrome (SPS) is a rare autoimmune disease caused by lack of inhibition to excitatory neurotransmitters in the central nervous system (CNS) leading to inappropriate motor unit firing. The pathophysiology is incompletely understood; however, high titers of antiglutamic acid decarboxylase antibody (anti-GAD Ab) are strongly associated with this disease. We present a 50-year-old woman with a history of ongoing gait and balance issues for 5 years with multiple negative workups. She recently had an acute exacerbation which left her bedbound, unable to move her legs or turn from side to side. After a negative workup at an outside hospital, the patient was discharged to a subacute rehabilitation facility. She then presented to our institution due to worsening of her condition and was ultimately diagnosed with SPS which was successfully treated. We review the case presentation and treatment options in the context of a severe disabling disease presentation. Hindawi 2022-01-13 /pmc/articles/PMC8776484/ /pubmed/35070465 http://dx.doi.org/10.1155/2022/7741545 Text en Copyright © 2022 Ruchi Yadav et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Yadav, Ruchi Abrol, Neeraj Terebelo, Sima One in a Million: A Case Report of Stiff Person Syndrome |
title | One in a Million: A Case Report of Stiff Person Syndrome |
title_full | One in a Million: A Case Report of Stiff Person Syndrome |
title_fullStr | One in a Million: A Case Report of Stiff Person Syndrome |
title_full_unstemmed | One in a Million: A Case Report of Stiff Person Syndrome |
title_short | One in a Million: A Case Report of Stiff Person Syndrome |
title_sort | one in a million: a case report of stiff person syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776484/ https://www.ncbi.nlm.nih.gov/pubmed/35070465 http://dx.doi.org/10.1155/2022/7741545 |
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