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Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy

RESULTS: Thirty-six, fifty-two, and seventy-nine MAs showed no, mild, and severe leakage on FA, respectively. Most MAs (61.7%) were centered in the inner nuclear layer. Cystoid spaces were observed adjacent to 60 (35.9%) MAs. MAs with severe leakage had a statistically higher flow proportion compare...

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Autores principales: Chen, Ruoyu, Liang, Anyi, Yao, Jie, Wang, Zicheng, Chen, Yesheng, Zhuang, Xuenan, Zeng, Yunkao, Zhang, Liang, Cao, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776493/
https://www.ncbi.nlm.nih.gov/pubmed/35071604
http://dx.doi.org/10.1155/2022/7723706
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author Chen, Ruoyu
Liang, Anyi
Yao, Jie
Wang, Zicheng
Chen, Yesheng
Zhuang, Xuenan
Zeng, Yunkao
Zhang, Liang
Cao, Dan
author_facet Chen, Ruoyu
Liang, Anyi
Yao, Jie
Wang, Zicheng
Chen, Yesheng
Zhuang, Xuenan
Zeng, Yunkao
Zhang, Liang
Cao, Dan
author_sort Chen, Ruoyu
collection PubMed
description RESULTS: Thirty-six, fifty-two, and seventy-nine MAs showed no, mild, and severe leakage on FA, respectively. Most MAs (61.7%) were centered in the inner nuclear layer. Cystoid spaces were observed adjacent to 60 (35.9%) MAs. MAs with severe leakage had a statistically higher flow proportion compared to MAs with no or mild leakage (both P < 0.001). Only 112 MAs (67.1%) were visualized in the OCTA en face images, while 165 MAs (98.8%) could be visualized in the OCT en face images. The location of MAs did not associate significantly with FA leakage status. The presence of nearby cystoid spaces and higher flow proportion by OCT B-scan with flow overlay correlated significantly with FA leakage status. CONCLUSION: The flow proportion of MAs observed on OCT B-scans with flow overlay might be a potential biomarker to identify leaking MAs. A combination of OCT B-scan, OCT en face, and OCTA en face images increased the detection rate of diabetic MAs in a noninvasive way.
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spelling pubmed-87764932022-01-21 Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy Chen, Ruoyu Liang, Anyi Yao, Jie Wang, Zicheng Chen, Yesheng Zhuang, Xuenan Zeng, Yunkao Zhang, Liang Cao, Dan J Diabetes Res Research Article RESULTS: Thirty-six, fifty-two, and seventy-nine MAs showed no, mild, and severe leakage on FA, respectively. Most MAs (61.7%) were centered in the inner nuclear layer. Cystoid spaces were observed adjacent to 60 (35.9%) MAs. MAs with severe leakage had a statistically higher flow proportion compared to MAs with no or mild leakage (both P < 0.001). Only 112 MAs (67.1%) were visualized in the OCTA en face images, while 165 MAs (98.8%) could be visualized in the OCT en face images. The location of MAs did not associate significantly with FA leakage status. The presence of nearby cystoid spaces and higher flow proportion by OCT B-scan with flow overlay correlated significantly with FA leakage status. CONCLUSION: The flow proportion of MAs observed on OCT B-scans with flow overlay might be a potential biomarker to identify leaking MAs. A combination of OCT B-scan, OCT en face, and OCTA en face images increased the detection rate of diabetic MAs in a noninvasive way. Hindawi 2022-01-13 /pmc/articles/PMC8776493/ /pubmed/35071604 http://dx.doi.org/10.1155/2022/7723706 Text en Copyright © 2022 Ruoyu Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Ruoyu
Liang, Anyi
Yao, Jie
Wang, Zicheng
Chen, Yesheng
Zhuang, Xuenan
Zeng, Yunkao
Zhang, Liang
Cao, Dan
Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy
title Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy
title_full Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy
title_fullStr Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy
title_full_unstemmed Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy
title_short Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy
title_sort fluorescein leakage and optical coherence tomography angiography features of microaneurysms in diabetic retinopathy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776493/
https://www.ncbi.nlm.nih.gov/pubmed/35071604
http://dx.doi.org/10.1155/2022/7723706
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