Cargando…
Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy
RESULTS: Thirty-six, fifty-two, and seventy-nine MAs showed no, mild, and severe leakage on FA, respectively. Most MAs (61.7%) were centered in the inner nuclear layer. Cystoid spaces were observed adjacent to 60 (35.9%) MAs. MAs with severe leakage had a statistically higher flow proportion compare...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776493/ https://www.ncbi.nlm.nih.gov/pubmed/35071604 http://dx.doi.org/10.1155/2022/7723706 |
_version_ | 1784636849573068800 |
---|---|
author | Chen, Ruoyu Liang, Anyi Yao, Jie Wang, Zicheng Chen, Yesheng Zhuang, Xuenan Zeng, Yunkao Zhang, Liang Cao, Dan |
author_facet | Chen, Ruoyu Liang, Anyi Yao, Jie Wang, Zicheng Chen, Yesheng Zhuang, Xuenan Zeng, Yunkao Zhang, Liang Cao, Dan |
author_sort | Chen, Ruoyu |
collection | PubMed |
description | RESULTS: Thirty-six, fifty-two, and seventy-nine MAs showed no, mild, and severe leakage on FA, respectively. Most MAs (61.7%) were centered in the inner nuclear layer. Cystoid spaces were observed adjacent to 60 (35.9%) MAs. MAs with severe leakage had a statistically higher flow proportion compared to MAs with no or mild leakage (both P < 0.001). Only 112 MAs (67.1%) were visualized in the OCTA en face images, while 165 MAs (98.8%) could be visualized in the OCT en face images. The location of MAs did not associate significantly with FA leakage status. The presence of nearby cystoid spaces and higher flow proportion by OCT B-scan with flow overlay correlated significantly with FA leakage status. CONCLUSION: The flow proportion of MAs observed on OCT B-scans with flow overlay might be a potential biomarker to identify leaking MAs. A combination of OCT B-scan, OCT en face, and OCTA en face images increased the detection rate of diabetic MAs in a noninvasive way. |
format | Online Article Text |
id | pubmed-8776493 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-87764932022-01-21 Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy Chen, Ruoyu Liang, Anyi Yao, Jie Wang, Zicheng Chen, Yesheng Zhuang, Xuenan Zeng, Yunkao Zhang, Liang Cao, Dan J Diabetes Res Research Article RESULTS: Thirty-six, fifty-two, and seventy-nine MAs showed no, mild, and severe leakage on FA, respectively. Most MAs (61.7%) were centered in the inner nuclear layer. Cystoid spaces were observed adjacent to 60 (35.9%) MAs. MAs with severe leakage had a statistically higher flow proportion compared to MAs with no or mild leakage (both P < 0.001). Only 112 MAs (67.1%) were visualized in the OCTA en face images, while 165 MAs (98.8%) could be visualized in the OCT en face images. The location of MAs did not associate significantly with FA leakage status. The presence of nearby cystoid spaces and higher flow proportion by OCT B-scan with flow overlay correlated significantly with FA leakage status. CONCLUSION: The flow proportion of MAs observed on OCT B-scans with flow overlay might be a potential biomarker to identify leaking MAs. A combination of OCT B-scan, OCT en face, and OCTA en face images increased the detection rate of diabetic MAs in a noninvasive way. Hindawi 2022-01-13 /pmc/articles/PMC8776493/ /pubmed/35071604 http://dx.doi.org/10.1155/2022/7723706 Text en Copyright © 2022 Ruoyu Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Chen, Ruoyu Liang, Anyi Yao, Jie Wang, Zicheng Chen, Yesheng Zhuang, Xuenan Zeng, Yunkao Zhang, Liang Cao, Dan Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy |
title | Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy |
title_full | Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy |
title_fullStr | Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy |
title_full_unstemmed | Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy |
title_short | Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy |
title_sort | fluorescein leakage and optical coherence tomography angiography features of microaneurysms in diabetic retinopathy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776493/ https://www.ncbi.nlm.nih.gov/pubmed/35071604 http://dx.doi.org/10.1155/2022/7723706 |
work_keys_str_mv | AT chenruoyu fluoresceinleakageandopticalcoherencetomographyangiographyfeaturesofmicroaneurysmsindiabeticretinopathy AT lianganyi fluoresceinleakageandopticalcoherencetomographyangiographyfeaturesofmicroaneurysmsindiabeticretinopathy AT yaojie fluoresceinleakageandopticalcoherencetomographyangiographyfeaturesofmicroaneurysmsindiabeticretinopathy AT wangzicheng fluoresceinleakageandopticalcoherencetomographyangiographyfeaturesofmicroaneurysmsindiabeticretinopathy AT chenyesheng fluoresceinleakageandopticalcoherencetomographyangiographyfeaturesofmicroaneurysmsindiabeticretinopathy AT zhuangxuenan fluoresceinleakageandopticalcoherencetomographyangiographyfeaturesofmicroaneurysmsindiabeticretinopathy AT zengyunkao fluoresceinleakageandopticalcoherencetomographyangiographyfeaturesofmicroaneurysmsindiabeticretinopathy AT zhangliang fluoresceinleakageandopticalcoherencetomographyangiographyfeaturesofmicroaneurysmsindiabeticretinopathy AT caodan fluoresceinleakageandopticalcoherencetomographyangiographyfeaturesofmicroaneurysmsindiabeticretinopathy |