Mutations in SARS-CoV-2 variants of concern link to increased spike cleavage and virus transmission

SARS-CoV-2 lineages have diverged into highly prevalent variants termed “variants of concern” (VOCs). Here, we characterized emerging SARS-CoV-2 spike polymorphisms in vitro and in vivo to understand their impact on transmissibility and virus pathogenicity and fitness. We demonstrate that the substi...

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Detalles Bibliográficos
Autores principales: Escalera, Alba, Gonzalez-Reiche, Ana S., Aslam, Sadaf, Mena, Ignacio, Laporte, Manon, Pearl, Rebecca L., Fossati, Andrea, Rathnasinghe, Raveen, Alshammary, Hala, van de Guchte, Adriana, Farrugia, Keith, Qin, Yiren, Bouhaddou, Mehdi, Kehrer, Thomas, Zuliani-Alvarez, Lorena, Meekins, David A., Balaraman, Velmurugan, McDowell, Chester, Richt, Jürgen A., Bajic, Goran, Sordillo, Emilia Mia, Dejosez, Marion, Zwaka, Thomas P., Krogan, Nevan J., Simon, Viviana, Albrecht, Randy A., van Bakel, Harm, García-Sastre, Adolfo, Aydillo, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776496/
https://www.ncbi.nlm.nih.gov/pubmed/35150638
http://dx.doi.org/10.1016/j.chom.2022.01.006

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