The Interaction Between N(6)-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers

N(6)-methyladenosine (m(6)A) is the most common epigenetic modification of eukaryotic RNA, which can participate in the growth and development of the body and a variety of physiological and disease processes by affecting the splicing, processing, localization, transport, translation, and degradation...

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Detalles Bibliográficos
Autores principales: Yao, Lin, Man, Chang-Feng, He, Rong, He, Lian, Huang, Jia-Bin, Xiang, Shou-Yan, Dai, Zhe, Wang, Xiao-Yan, Fan, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776638/
https://www.ncbi.nlm.nih.gov/pubmed/35070987
http://dx.doi.org/10.3389/fonc.2021.784127
Descripción
Sumario:N(6)-methyladenosine (m(6)A) is the most common epigenetic modification of eukaryotic RNA, which can participate in the growth and development of the body and a variety of physiological and disease processes by affecting the splicing, processing, localization, transport, translation, and degradation of RNA. Increasing evidence shows that non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, can also regulate the RNA m(6)A modification process by affecting the expression of m(6)A-related enzymes. The interaction between m(6)A modification and non-coding RNAs provides a new perspective for the exploration of the potential mechanism of tumor genesis and development. In this review, we summarize the potential mechanisms and effects of m(6)A and non-coding RNAs in gastrointestinal tract cancers.

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