The Interaction Between N(6)-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers

N(6)-methyladenosine (m(6)A) is the most common epigenetic modification of eukaryotic RNA, which can participate in the growth and development of the body and a variety of physiological and disease processes by affecting the splicing, processing, localization, transport, translation, and degradation...

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Autores principales: Yao, Lin, Man, Chang-Feng, He, Rong, He, Lian, Huang, Jia-Bin, Xiang, Shou-Yan, Dai, Zhe, Wang, Xiao-Yan, Fan, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776638/
https://www.ncbi.nlm.nih.gov/pubmed/35070987
http://dx.doi.org/10.3389/fonc.2021.784127
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author Yao, Lin
Man, Chang-Feng
He, Rong
He, Lian
Huang, Jia-Bin
Xiang, Shou-Yan
Dai, Zhe
Wang, Xiao-Yan
Fan, Yu
author_facet Yao, Lin
Man, Chang-Feng
He, Rong
He, Lian
Huang, Jia-Bin
Xiang, Shou-Yan
Dai, Zhe
Wang, Xiao-Yan
Fan, Yu
author_sort Yao, Lin
collection PubMed
description N(6)-methyladenosine (m(6)A) is the most common epigenetic modification of eukaryotic RNA, which can participate in the growth and development of the body and a variety of physiological and disease processes by affecting the splicing, processing, localization, transport, translation, and degradation of RNA. Increasing evidence shows that non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, can also regulate the RNA m(6)A modification process by affecting the expression of m(6)A-related enzymes. The interaction between m(6)A modification and non-coding RNAs provides a new perspective for the exploration of the potential mechanism of tumor genesis and development. In this review, we summarize the potential mechanisms and effects of m(6)A and non-coding RNAs in gastrointestinal tract cancers.
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spelling pubmed-87766382022-01-22 The Interaction Between N(6)-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers Yao, Lin Man, Chang-Feng He, Rong He, Lian Huang, Jia-Bin Xiang, Shou-Yan Dai, Zhe Wang, Xiao-Yan Fan, Yu Front Oncol Oncology N(6)-methyladenosine (m(6)A) is the most common epigenetic modification of eukaryotic RNA, which can participate in the growth and development of the body and a variety of physiological and disease processes by affecting the splicing, processing, localization, transport, translation, and degradation of RNA. Increasing evidence shows that non-coding RNAs, particularly microRNA, long non-coding RNA, and circular RNA, can also regulate the RNA m(6)A modification process by affecting the expression of m(6)A-related enzymes. The interaction between m(6)A modification and non-coding RNAs provides a new perspective for the exploration of the potential mechanism of tumor genesis and development. In this review, we summarize the potential mechanisms and effects of m(6)A and non-coding RNAs in gastrointestinal tract cancers. Frontiers Media S.A. 2022-01-07 /pmc/articles/PMC8776638/ /pubmed/35070987 http://dx.doi.org/10.3389/fonc.2021.784127 Text en Copyright © 2021 Yao, Man, He, He, Huang, Xiang, Dai, Wang and Fan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Yao, Lin
Man, Chang-Feng
He, Rong
He, Lian
Huang, Jia-Bin
Xiang, Shou-Yan
Dai, Zhe
Wang, Xiao-Yan
Fan, Yu
The Interaction Between N(6)-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers
title The Interaction Between N(6)-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers
title_full The Interaction Between N(6)-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers
title_fullStr The Interaction Between N(6)-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers
title_full_unstemmed The Interaction Between N(6)-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers
title_short The Interaction Between N(6)-Methyladenosine Modification and Non-Coding RNAs in Gastrointestinal Tract Cancers
title_sort interaction between n(6)-methyladenosine modification and non-coding rnas in gastrointestinal tract cancers
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776638/
https://www.ncbi.nlm.nih.gov/pubmed/35070987
http://dx.doi.org/10.3389/fonc.2021.784127
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