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Small dose of oral gastrografin for computed tomography-based image-guided brachytherapy in patients with uterine cervical cancer

Oral administration of a water-soluble iodine contrast agent (gastrografin) was reported to assist in the appropriate contouring of the small intestine on computed tomography (CT)-based radiotherapy (RT) planning. The efficacy and optimal dose of gastrografin in CT-based image-guided brachytherapy (...

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Autores principales: Maemoto, Hitoshi, Ogura, Takuto, Toita, Takafumi, Ariga, Takuro, Hashimoto, Seiji, Kawakami, Yuka, Ishikawa, Kazuki, Takehara, Shota, Heianna, Joichi, Kudaka, Wataru, Aoki, Yoichi, Nishie, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776687/
https://www.ncbi.nlm.nih.gov/pubmed/34718687
http://dx.doi.org/10.1093/jrr/rrab102
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author Maemoto, Hitoshi
Ogura, Takuto
Toita, Takafumi
Ariga, Takuro
Hashimoto, Seiji
Kawakami, Yuka
Ishikawa, Kazuki
Takehara, Shota
Heianna, Joichi
Kudaka, Wataru
Aoki, Yoichi
Nishie, Akihiro
author_facet Maemoto, Hitoshi
Ogura, Takuto
Toita, Takafumi
Ariga, Takuro
Hashimoto, Seiji
Kawakami, Yuka
Ishikawa, Kazuki
Takehara, Shota
Heianna, Joichi
Kudaka, Wataru
Aoki, Yoichi
Nishie, Akihiro
author_sort Maemoto, Hitoshi
collection PubMed
description Oral administration of a water-soluble iodine contrast agent (gastrografin) was reported to assist in the appropriate contouring of the small intestine on computed tomography (CT)-based radiotherapy (RT) planning. The efficacy and optimal dose of gastrografin in CT-based image-guided brachytherapy (IGBT) for cervical cancer remain unknown. This study aimed to investigate the efficacy of pretreatment oral administration of gastrografin at a small dose of 50 ml in CT-based IGBT for cervical cancer. A total of 422 sessions in 137 patients who underwent CT-based IGBT with 50 ml of oral gastrografin (concentration, 3% or 4%) were analyzed. Preparation of gastrografin was judged as effective when the small intestine was contrast-enhanced at the area where the small intestine was in contact with the uterus/adnexa. About 287 out of 422 sessions (68%) were judged as effective with gastrografin preparation. The 135 ineffective sessions were considered as follows: (i) the contrast enhancement of the small intestine was not confirmed (n = 36), (ii) the small intestine was not in contact with the uterus/adnexa despite the confirmation of the contrast enhancement of the small intestine (n = 34), and (iii) gastrografin was absent in the small intestine at the area in contact with the uterus/adnexa, even when gastrografin was observed in the small intestine at the area not in contact with the uterus/adnexa (n = 65). In conclusion, pretreatment oral administration of a small dose gastrografin achieved moderate efficacy for accurate contouring of the small intestine close to the uterus/adnexa in CT-based IGBT for cervical cancer.
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spelling pubmed-87766872022-01-21 Small dose of oral gastrografin for computed tomography-based image-guided brachytherapy in patients with uterine cervical cancer Maemoto, Hitoshi Ogura, Takuto Toita, Takafumi Ariga, Takuro Hashimoto, Seiji Kawakami, Yuka Ishikawa, Kazuki Takehara, Shota Heianna, Joichi Kudaka, Wataru Aoki, Yoichi Nishie, Akihiro J Radiat Res Oncology/Medicine Oral administration of a water-soluble iodine contrast agent (gastrografin) was reported to assist in the appropriate contouring of the small intestine on computed tomography (CT)-based radiotherapy (RT) planning. The efficacy and optimal dose of gastrografin in CT-based image-guided brachytherapy (IGBT) for cervical cancer remain unknown. This study aimed to investigate the efficacy of pretreatment oral administration of gastrografin at a small dose of 50 ml in CT-based IGBT for cervical cancer. A total of 422 sessions in 137 patients who underwent CT-based IGBT with 50 ml of oral gastrografin (concentration, 3% or 4%) were analyzed. Preparation of gastrografin was judged as effective when the small intestine was contrast-enhanced at the area where the small intestine was in contact with the uterus/adnexa. About 287 out of 422 sessions (68%) were judged as effective with gastrografin preparation. The 135 ineffective sessions were considered as follows: (i) the contrast enhancement of the small intestine was not confirmed (n = 36), (ii) the small intestine was not in contact with the uterus/adnexa despite the confirmation of the contrast enhancement of the small intestine (n = 34), and (iii) gastrografin was absent in the small intestine at the area in contact with the uterus/adnexa, even when gastrografin was observed in the small intestine at the area not in contact with the uterus/adnexa (n = 65). In conclusion, pretreatment oral administration of a small dose gastrografin achieved moderate efficacy for accurate contouring of the small intestine close to the uterus/adnexa in CT-based IGBT for cervical cancer. Oxford University Press 2021-10-29 /pmc/articles/PMC8776687/ /pubmed/34718687 http://dx.doi.org/10.1093/jrr/rrab102 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Oncology/Medicine
Maemoto, Hitoshi
Ogura, Takuto
Toita, Takafumi
Ariga, Takuro
Hashimoto, Seiji
Kawakami, Yuka
Ishikawa, Kazuki
Takehara, Shota
Heianna, Joichi
Kudaka, Wataru
Aoki, Yoichi
Nishie, Akihiro
Small dose of oral gastrografin for computed tomography-based image-guided brachytherapy in patients with uterine cervical cancer
title Small dose of oral gastrografin for computed tomography-based image-guided brachytherapy in patients with uterine cervical cancer
title_full Small dose of oral gastrografin for computed tomography-based image-guided brachytherapy in patients with uterine cervical cancer
title_fullStr Small dose of oral gastrografin for computed tomography-based image-guided brachytherapy in patients with uterine cervical cancer
title_full_unstemmed Small dose of oral gastrografin for computed tomography-based image-guided brachytherapy in patients with uterine cervical cancer
title_short Small dose of oral gastrografin for computed tomography-based image-guided brachytherapy in patients with uterine cervical cancer
title_sort small dose of oral gastrografin for computed tomography-based image-guided brachytherapy in patients with uterine cervical cancer
topic Oncology/Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776687/
https://www.ncbi.nlm.nih.gov/pubmed/34718687
http://dx.doi.org/10.1093/jrr/rrab102
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