Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1

Mitochondrial dysfunction is implicated in skeletal muscle insulin resistance. Syntaxin 4 (STX4) levels are reduced in human diabetic skeletal muscle, and global transgenic enrichment of STX4 expression improves insulin sensitivity in mice. Here, we show that transgenic skeletal muscle-specific STX4...

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Detalles Bibliográficos
Autores principales: Merz, Karla E., Hwang, Jinhee, Zhou, Chunxue, Veluthakal, Rajakrishnan, McCown, Erika M., Hamilton, Angelica, Oh, Eunjin, Dai, Wenting, Fueger, Patrick T., Jiang, Lei, Huss, Janice. M., Thurmond, Debbie C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776765/
https://www.ncbi.nlm.nih.gov/pubmed/35058456
http://dx.doi.org/10.1038/s41467-022-28061-w

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