Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids

Microglia play a role in the emergence and preservation of a healthy brain microenvironment. Dysfunction of microglia has been associated with neurodevelopmental and neurodegenerative disorders. Investigating the function of human microglia in health and disease has been challenging due to the limit...

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Detalles Bibliográficos
Autores principales: Cakir, Bilal, Tanaka, Yoshiaki, Kiral, Ferdi Ridvan, Xiang, Yangfei, Dagliyan, Onur, Wang, Juan, Lee, Maria, Greaney, Allison M., Yang, Woo Sub, duBoulay, Catherine, Kural, Mehmet Hamdi, Patterson, Benjamin, Zhong, Mei, Kim, Jonghun, Bai, Yalai, Min, Wang, Niklason, Laura E., Patra, Prabir, Park, In-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776770/
https://www.ncbi.nlm.nih.gov/pubmed/35058453
http://dx.doi.org/10.1038/s41467-022-28043-y

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