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Little genomic support for Cyclophilin A-matrix metalloproteinase-9 pathway as a therapeutic target for cognitive impairment in APOE4 carriers

Therapeutic targets for halting the progression of Alzheimer’s disease pathology are lacking. Recent evidence suggests that APOE4, but not APOE3, activates the Cyclophilin-A matrix metalloproteinase-9 (CypA-MMP9) pathway, leading to an accelerated breakdown of the blood–brain barrier (BBB) and there...

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Detalles Bibliográficos
Autores principales:	Anderson, Emma L., Williams, Dylan M., Walker, Venexia M., Davies, Neil M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776806/ https://www.ncbi.nlm.nih.gov/pubmed/35058547 http://dx.doi.org/10.1038/s41598-022-05225-8

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