RBL2/DREAM-mediated repression of the Aurora kinase A/B pathway determines therapy responsiveness and outcome in p53 WT NSCLC

Wild-type p53 is a stress-responsive transcription factor and potent tumor suppressor. P53 activates or represses genes involved in cell cycle progression or apoptosis in order to arrest the cell cycle or induce cell death. Transcription repression by p53 is indirect and requires repressive members...

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Detalles Bibliográficos
Autores principales: Duan, Lei, Perez, Ricardo E., Calhoun, Sarah, Maki, Carl G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776870/
https://www.ncbi.nlm.nih.gov/pubmed/35058503
http://dx.doi.org/10.1038/s41598-022-05013-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776870/
https://www.ncbi.nlm.nih.gov/pubmed/35058503
http://dx.doi.org/10.1038/s41598-022-05013-4

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