A comprehensive physiologically based pharmacokinetic (PBPK) model for nicotine in humans from using nicotine-containing products with different routes of exposure

Physiologically based pharmacokinetic (PBPK) modeling can be a useful tool for characterizing nicotine pharmacokinetics (PK) from use of tobacco products. We expand a previously published PBPK model to simulate a nicotine PK profile, following single or multiple use of various tobacco products [ciga...

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Detalles Bibliográficos
Autores principales: Rostami, Ali A., Campbell, Jerry L., Pithawalla, Yezdi B., Pourhashem, Hamideh, Muhammad-Kah, Raheema S., Sarkar, Mohamadi A., Liu, Jianmin, McKinney, Willie J., Gentry, Robinan, Gogova, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776883/
https://www.ncbi.nlm.nih.gov/pubmed/35058535
http://dx.doi.org/10.1038/s41598-022-05108-y

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