5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding

Obesity is primarily a consequence of consuming calories beyond energetic requirements, but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons in the dorsal Raphe nucleus (5-HT(DRN)) regulate different types of feeding behavior, such as eating to cope with hunger or...

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Autores principales: He, Yanlin, Cai, Xing, Liu, Hailan, Conde, Krisitine M., Xu, Pingwen, Li, Yongxiang, Wang, Chunmei, Yu, Meng, He, Yang, Liu, Hesong, Liang, Chen, Yang, Tingting, Yang, Yongjie, Yu, Kaifan, Wang, Julia, Zheng, Rong, Liu, Feng, Sun, Zheng, Heisler, Lora, Wu, Qi, Tong, Qingchun, Zhu, Canjun, Shu, Gang, Xu, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776930/
https://www.ncbi.nlm.nih.gov/pubmed/34290371
http://dx.doi.org/10.1038/s41380-021-01220-z
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author He, Yanlin
Cai, Xing
Liu, Hailan
Conde, Krisitine M.
Xu, Pingwen
Li, Yongxiang
Wang, Chunmei
Yu, Meng
He, Yang
Liu, Hesong
Liang, Chen
Yang, Tingting
Yang, Yongjie
Yu, Kaifan
Wang, Julia
Zheng, Rong
Liu, Feng
Sun, Zheng
Heisler, Lora
Wu, Qi
Tong, Qingchun
Zhu, Canjun
Shu, Gang
Xu, Yong
author_facet He, Yanlin
Cai, Xing
Liu, Hailan
Conde, Krisitine M.
Xu, Pingwen
Li, Yongxiang
Wang, Chunmei
Yu, Meng
He, Yang
Liu, Hesong
Liang, Chen
Yang, Tingting
Yang, Yongjie
Yu, Kaifan
Wang, Julia
Zheng, Rong
Liu, Feng
Sun, Zheng
Heisler, Lora
Wu, Qi
Tong, Qingchun
Zhu, Canjun
Shu, Gang
Xu, Yong
author_sort He, Yanlin
collection PubMed
description Obesity is primarily a consequence of consuming calories beyond energetic requirements, but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons in the dorsal Raphe nucleus (5-HT(DRN)) regulate different types of feeding behavior, such as eating to cope with hunger or for pleasure. Here, we observed that activation of 5-HT(DRN) to hypothalamic arcuate nucleus (5-HT(DRN) → ARH) projections inhibits food intake driven by hunger via actions at ARH 5-HT(2C) and 5-HT(1B) receptors, whereas activation of 5-HT(DRN) to ventral tegmental area (5-HT(DRN) → VTA) projections inhibits non-hunger-driven feeding via actions at 5-HT(2C) receptors. Further, hunger-driven feeding gradually activates ARH-projecting 5-HT(DRN) neurons via inhibiting their responsiveness to inhibitory GABAergic inputs; non-hunger-driven feeding activates VTA-projecting 5-HT(DRN) neurons through reducing a potassium outward current. Thus, our results support a model whereby parallel circuits modulate feeding behavior either in response to hunger or to hunger-independent cues.
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spelling pubmed-87769302022-02-26 5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding He, Yanlin Cai, Xing Liu, Hailan Conde, Krisitine M. Xu, Pingwen Li, Yongxiang Wang, Chunmei Yu, Meng He, Yang Liu, Hesong Liang, Chen Yang, Tingting Yang, Yongjie Yu, Kaifan Wang, Julia Zheng, Rong Liu, Feng Sun, Zheng Heisler, Lora Wu, Qi Tong, Qingchun Zhu, Canjun Shu, Gang Xu, Yong Mol Psychiatry Article Obesity is primarily a consequence of consuming calories beyond energetic requirements, but underpinning drivers have not been fully defined. 5-Hydroxytryptamine (5-HT) neurons in the dorsal Raphe nucleus (5-HT(DRN)) regulate different types of feeding behavior, such as eating to cope with hunger or for pleasure. Here, we observed that activation of 5-HT(DRN) to hypothalamic arcuate nucleus (5-HT(DRN) → ARH) projections inhibits food intake driven by hunger via actions at ARH 5-HT(2C) and 5-HT(1B) receptors, whereas activation of 5-HT(DRN) to ventral tegmental area (5-HT(DRN) → VTA) projections inhibits non-hunger-driven feeding via actions at 5-HT(2C) receptors. Further, hunger-driven feeding gradually activates ARH-projecting 5-HT(DRN) neurons via inhibiting their responsiveness to inhibitory GABAergic inputs; non-hunger-driven feeding activates VTA-projecting 5-HT(DRN) neurons through reducing a potassium outward current. Thus, our results support a model whereby parallel circuits modulate feeding behavior either in response to hunger or to hunger-independent cues. Nature Publishing Group UK 2021-07-21 2021 /pmc/articles/PMC8776930/ /pubmed/34290371 http://dx.doi.org/10.1038/s41380-021-01220-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
He, Yanlin
Cai, Xing
Liu, Hailan
Conde, Krisitine M.
Xu, Pingwen
Li, Yongxiang
Wang, Chunmei
Yu, Meng
He, Yang
Liu, Hesong
Liang, Chen
Yang, Tingting
Yang, Yongjie
Yu, Kaifan
Wang, Julia
Zheng, Rong
Liu, Feng
Sun, Zheng
Heisler, Lora
Wu, Qi
Tong, Qingchun
Zhu, Canjun
Shu, Gang
Xu, Yong
5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding
title 5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding
title_full 5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding
title_fullStr 5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding
title_full_unstemmed 5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding
title_short 5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding
title_sort 5-ht recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776930/
https://www.ncbi.nlm.nih.gov/pubmed/34290371
http://dx.doi.org/10.1038/s41380-021-01220-z
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