Pcyt2 deficiency causes age-dependant development of nonalcoholic steatohepatitis and insulin resistance that could be attenuated with phosphonoethylamine

The mechanisms of NASH development in the context of age and genetics are not fully elucidated. This study investigates the age-dependent liver defects during NASH development in mice with heterozygous deletion of Pcyt2 (Pcyt2(+/−)), the rate limiting enzyme in phosphatidylethanolamine (PE) synthesi...

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Detalles Bibliográficos
Autores principales: Grapentine, Sophie, Singh, Rathnesh K., Basu, Poulami, Sivanesan, Sugashan, Mattos, Gabriela, Oresajo, Oreoluwa, Cheema, Jasmine, Demeke, Wendwesen, Dolinsky, Vernon W., Bakovic, Marica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776951/
https://www.ncbi.nlm.nih.gov/pubmed/35058529
http://dx.doi.org/10.1038/s41598-022-05140-y

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