PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis

In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson’s disease (PD). However, difficulty in detecting endogenous PINK1 protein in rodent brains and cell lines has prevented the rigorous inv...

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Detalles Bibliográficos
Autores principales: Yang, Weili, Guo, Xiangyu, Tu, Zhuchi, Chen, Xiusheng, Han, Rui, Liu, Yanting, Yan, Sen, Wang, Qi, Wang, Zhifu, Zhao, Xianxian, Zhang, Yunpeng, Xiong, Xin, Yang, Huiming, Yin, Peng, Wan, Huida, Chen, Xingxing, Guo, Jifeng, Yan, Xiao-Xin, Liao, Lujian, Li, Shihua, Li, Xiao-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8776976/
https://www.ncbi.nlm.nih.gov/pubmed/34800266
http://dx.doi.org/10.1007/s13238-021-00888-x

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