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Bioactivity of Inhaled Methane and Interactions With Other Biological Gases
A number of studies have demonstrated explicit bioactivity for exogenous methane (CH(4)), even though it is conventionally considered as physiologically inert. Other reports cited in this review have demonstrated that inhaled, normoxic air-CH(4) mixtures can modulate the in vivo pathways involved in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777024/ https://www.ncbi.nlm.nih.gov/pubmed/35071248 http://dx.doi.org/10.3389/fcell.2021.824749 |
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author | Juhász, László Tallósy, Szabolcs Péter Nászai, Anna Varga, Gabriella Érces, Dániel Boros, Mihály |
author_facet | Juhász, László Tallósy, Szabolcs Péter Nászai, Anna Varga, Gabriella Érces, Dániel Boros, Mihály |
author_sort | Juhász, László |
collection | PubMed |
description | A number of studies have demonstrated explicit bioactivity for exogenous methane (CH(4)), even though it is conventionally considered as physiologically inert. Other reports cited in this review have demonstrated that inhaled, normoxic air-CH(4) mixtures can modulate the in vivo pathways involved in oxidative and nitrosative stress responses and key events of mitochondrial respiration and apoptosis. The overview is divided into two parts, the first being devoted to a brief review of the effects of biologically important gases in the context of hypoxia, while the second part deals with CH(4) bioactivity. Finally, the consequence of exogenous, normoxic CH(4) administration is discussed under experimental hypoxia- or ischaemia-linked conditions and in interactions between CH(4) and other biological gases, with a special emphasis on its versatile effects demonstrated in pulmonary pathologies. |
format | Online Article Text |
id | pubmed-8777024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87770242022-01-22 Bioactivity of Inhaled Methane and Interactions With Other Biological Gases Juhász, László Tallósy, Szabolcs Péter Nászai, Anna Varga, Gabriella Érces, Dániel Boros, Mihály Front Cell Dev Biol Cell and Developmental Biology A number of studies have demonstrated explicit bioactivity for exogenous methane (CH(4)), even though it is conventionally considered as physiologically inert. Other reports cited in this review have demonstrated that inhaled, normoxic air-CH(4) mixtures can modulate the in vivo pathways involved in oxidative and nitrosative stress responses and key events of mitochondrial respiration and apoptosis. The overview is divided into two parts, the first being devoted to a brief review of the effects of biologically important gases in the context of hypoxia, while the second part deals with CH(4) bioactivity. Finally, the consequence of exogenous, normoxic CH(4) administration is discussed under experimental hypoxia- or ischaemia-linked conditions and in interactions between CH(4) and other biological gases, with a special emphasis on its versatile effects demonstrated in pulmonary pathologies. Frontiers Media S.A. 2022-01-07 /pmc/articles/PMC8777024/ /pubmed/35071248 http://dx.doi.org/10.3389/fcell.2021.824749 Text en Copyright © 2022 Juhász, Tallósy, Nászai, Varga, Érces and Boros. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Juhász, László Tallósy, Szabolcs Péter Nászai, Anna Varga, Gabriella Érces, Dániel Boros, Mihály Bioactivity of Inhaled Methane and Interactions With Other Biological Gases |
title | Bioactivity of Inhaled Methane and Interactions With Other Biological Gases |
title_full | Bioactivity of Inhaled Methane and Interactions With Other Biological Gases |
title_fullStr | Bioactivity of Inhaled Methane and Interactions With Other Biological Gases |
title_full_unstemmed | Bioactivity of Inhaled Methane and Interactions With Other Biological Gases |
title_short | Bioactivity of Inhaled Methane and Interactions With Other Biological Gases |
title_sort | bioactivity of inhaled methane and interactions with other biological gases |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777024/ https://www.ncbi.nlm.nih.gov/pubmed/35071248 http://dx.doi.org/10.3389/fcell.2021.824749 |
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