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Adverse renal effects of NLRP3 inflammasome inhibition by MCC950 in an interventional model of diabetic kidney disease

Activation of nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3) inflammasome has been reported in diabetic complications including diabetic kidney disease (DKD). However, it remains unknown if NLRP3 inhibition is renoprotective in a clinically relevant interve...

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Detalles Bibliográficos
Autores principales:	Østergaard, Jakob A., Jha, Jay C., Sharma, Arpeeta, Dai, Aozhi, Choi, Judy S.Y., de Haan, Judy B., Cooper, Mark E., Jandeleit-Dahm, Karin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2022
Materias:	Diabetes & Metabolic Disorders
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777085/ https://www.ncbi.nlm.nih.gov/pubmed/35048962 http://dx.doi.org/10.1042/CS20210865

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