Cargando…

Supplementing young cattle with a rumen-protected grape extract around vaccination increases humoral response and antioxidant defenses

Vaccination is an important mainstay of biosecurity and disease prevention in livestock farming. Vaccination failures represent an economic burden for the farmer. Polyphenol supplementation, known for its antioxidant properties, could help reduce oxidative damage and improve the success of vaccinati...

Descripción completa

Detalles Bibliográficos
Autores principales: Engler, Paul, Desguerets, Clémence, Benarbia, Mohamed El Amine, Mallem, Yassine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777116/
https://www.ncbi.nlm.nih.gov/pubmed/35079659
http://dx.doi.org/10.1016/j.vas.2022.100232
_version_ 1784636992629243904
author Engler, Paul
Desguerets, Clémence
Benarbia, Mohamed El Amine
Mallem, Yassine
author_facet Engler, Paul
Desguerets, Clémence
Benarbia, Mohamed El Amine
Mallem, Yassine
author_sort Engler, Paul
collection PubMed
description Vaccination is an important mainstay of biosecurity and disease prevention in livestock farming. Vaccination failures represent an economic burden for the farmer. Polyphenol supplementation, known for its antioxidant properties, could help reduce oxidative damage and improve the success of vaccination. We evaluated the effect of a rumen-protected grape extract (RPGE) supplementation around vaccination on the immune response in young ruminants. 22 young female cattle (aged 6 to 8 months), born in the same dairy farm, were randomly divided into 2 groups. One group (BP-O, n = 11) was supplemented with a RPGE (Nor-Grape® BP-O, Nor-Feed, France), whilst a control group (CTL, n = 11) was not. All animals were vaccinated (D14) with an inactivated vaccine against PI-3 V and BRSV. A booster was given 3 weeks later (D35). Supplementation began 15 days before vaccination (D0) and ended 15 days after the last injection (D49). Antibody titers and total antioxidant status (TAS) were performed on blood samples drawn on D0, D35 and D56. Results show that the BP-O group tended to have a greater overall antibody response to BRSV and PI-3 V on D56 (P < 0.10) and PI-3 V titer was significantly higher in the BP-O group on D35 (p < 0.05). A greater total antioxidant capacity (P<0.05 at D56) was also observed in the supplemented group. Results also showed a strong correlation between PI-3 V antibody titers and TAS (p < 0.001). Thus, since supplemented animals became seropositive faster and long-term immunity appeared to be improved, this supplementation strategy could be of interest to enhance the immune response during a vaccination episode by reducing oxidative stress.
format Online
Article
Text
id pubmed-8777116
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-87771162022-01-24 Supplementing young cattle with a rumen-protected grape extract around vaccination increases humoral response and antioxidant defenses Engler, Paul Desguerets, Clémence Benarbia, Mohamed El Amine Mallem, Yassine Vet Anim Sci Article Vaccination is an important mainstay of biosecurity and disease prevention in livestock farming. Vaccination failures represent an economic burden for the farmer. Polyphenol supplementation, known for its antioxidant properties, could help reduce oxidative damage and improve the success of vaccination. We evaluated the effect of a rumen-protected grape extract (RPGE) supplementation around vaccination on the immune response in young ruminants. 22 young female cattle (aged 6 to 8 months), born in the same dairy farm, were randomly divided into 2 groups. One group (BP-O, n = 11) was supplemented with a RPGE (Nor-Grape® BP-O, Nor-Feed, France), whilst a control group (CTL, n = 11) was not. All animals were vaccinated (D14) with an inactivated vaccine against PI-3 V and BRSV. A booster was given 3 weeks later (D35). Supplementation began 15 days before vaccination (D0) and ended 15 days after the last injection (D49). Antibody titers and total antioxidant status (TAS) were performed on blood samples drawn on D0, D35 and D56. Results show that the BP-O group tended to have a greater overall antibody response to BRSV and PI-3 V on D56 (P < 0.10) and PI-3 V titer was significantly higher in the BP-O group on D35 (p < 0.05). A greater total antioxidant capacity (P<0.05 at D56) was also observed in the supplemented group. Results also showed a strong correlation between PI-3 V antibody titers and TAS (p < 0.001). Thus, since supplemented animals became seropositive faster and long-term immunity appeared to be improved, this supplementation strategy could be of interest to enhance the immune response during a vaccination episode by reducing oxidative stress. Elsevier 2022-01-14 /pmc/articles/PMC8777116/ /pubmed/35079659 http://dx.doi.org/10.1016/j.vas.2022.100232 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Engler, Paul
Desguerets, Clémence
Benarbia, Mohamed El Amine
Mallem, Yassine
Supplementing young cattle with a rumen-protected grape extract around vaccination increases humoral response and antioxidant defenses
title Supplementing young cattle with a rumen-protected grape extract around vaccination increases humoral response and antioxidant defenses
title_full Supplementing young cattle with a rumen-protected grape extract around vaccination increases humoral response and antioxidant defenses
title_fullStr Supplementing young cattle with a rumen-protected grape extract around vaccination increases humoral response and antioxidant defenses
title_full_unstemmed Supplementing young cattle with a rumen-protected grape extract around vaccination increases humoral response and antioxidant defenses
title_short Supplementing young cattle with a rumen-protected grape extract around vaccination increases humoral response and antioxidant defenses
title_sort supplementing young cattle with a rumen-protected grape extract around vaccination increases humoral response and antioxidant defenses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777116/
https://www.ncbi.nlm.nih.gov/pubmed/35079659
http://dx.doi.org/10.1016/j.vas.2022.100232
work_keys_str_mv AT englerpaul supplementingyoungcattlewitharumenprotectedgrapeextractaroundvaccinationincreaseshumoralresponseandantioxidantdefenses
AT desgueretsclemence supplementingyoungcattlewitharumenprotectedgrapeextractaroundvaccinationincreaseshumoralresponseandantioxidantdefenses
AT benarbiamohamedelamine supplementingyoungcattlewitharumenprotectedgrapeextractaroundvaccinationincreaseshumoralresponseandantioxidantdefenses
AT mallemyassine supplementingyoungcattlewitharumenprotectedgrapeextractaroundvaccinationincreaseshumoralresponseandantioxidantdefenses