Destabilization of macrophage migration inhibitory factor by 4‐IPP reduces NF‐κB/P‐TEFb complex‐mediated c‐Myb transcription to suppress osteosarcoma tumourigenesis

BACKGROUND: As an inflammatory factor and oncogenic driver protein, the pleiotropic cytokine macrophage migration inhibitory factor (MIF) plays a crucial role in the osteosarcoma microenvironment. Although 4‐iodo‐6‐phenylpyrimidine (4‐IPP) can inactivate MIF biological functions, its anti‐osteosarco...

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Detalles Bibliográficos
Autores principales: Zheng, Lin, Feng, Zhenhua, Tao, Siyue, Gao, Jiawei, Lin, Ye, Wei, Xiaoan, Zheng, Bingjie, Huang, Bao, Zheng, Zeyu, Zhang, Xuyang, Liu, Junhui, Shan, Zhi, Chen, Yilei, Chen, Jian, Zhao, Fengdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777168/
https://www.ncbi.nlm.nih.gov/pubmed/35060345
http://dx.doi.org/10.1002/ctm2.652

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