Cargando…

Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis

Background: Early-onset psychosis (EOP) is among the leading causes of disease burden in adolescents. Negative symptoms and cognitive deficits predicts poorer functional outcome. A better understanding of the association between negative symptoms and cognitive impairment may inform theories on under...

Descripción completa

Detalles Bibliográficos
Autores principales: Mørch-Johnsen, Lynn, Smelror, Runar Elle, Andreou, Dimitrios, Barth, Claudia, Johannessen, Cecilie, Wedervang-Resell, Kirsten, Wortinger, Laura A., Díaz, Ricardo, Victoria, Gamaliel, Ueland, Torill, Andreassen, Ole A., Myhre, Anne M., Rund, Bjørn Rishovd, Ulloa, Rosa Elena, Agartz, Ingrid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777217/
https://www.ncbi.nlm.nih.gov/pubmed/35069300
http://dx.doi.org/10.3389/fpsyt.2021.825681
_version_ 1784637016003051520
author Mørch-Johnsen, Lynn
Smelror, Runar Elle
Andreou, Dimitrios
Barth, Claudia
Johannessen, Cecilie
Wedervang-Resell, Kirsten
Wortinger, Laura A.
Díaz, Ricardo
Victoria, Gamaliel
Ueland, Torill
Andreassen, Ole A.
Myhre, Anne M.
Rund, Bjørn Rishovd
Ulloa, Rosa Elena
Agartz, Ingrid
author_facet Mørch-Johnsen, Lynn
Smelror, Runar Elle
Andreou, Dimitrios
Barth, Claudia
Johannessen, Cecilie
Wedervang-Resell, Kirsten
Wortinger, Laura A.
Díaz, Ricardo
Victoria, Gamaliel
Ueland, Torill
Andreassen, Ole A.
Myhre, Anne M.
Rund, Bjørn Rishovd
Ulloa, Rosa Elena
Agartz, Ingrid
author_sort Mørch-Johnsen, Lynn
collection PubMed
description Background: Early-onset psychosis (EOP) is among the leading causes of disease burden in adolescents. Negative symptoms and cognitive deficits predicts poorer functional outcome. A better understanding of the association between negative symptoms and cognitive impairment may inform theories on underlying mechanisms and elucidate targets for development of new treatments. Two domains of negative symptoms have been described in adult patients with schizophrenia: apathy and diminished expression, however, the factorial structure of negative symptoms has not been investigated in EOP. We aimed to explore the factorial structure of negative symptoms and investigate associations between cognitive performance and negative symptom domains in adolescents with EOP. We hypothesized that (1) two negative symptom factors would be identifiable, and that (2) diminished expression would be more strongly associated with cognitive performance, similar to adult psychosis patients. Methods: Adolescent patients with non-affective EOP (n = 169) were included from three cohorts: Youth-TOP, Norway (n = 45), Early-Onset Study, Norway (n = 27) and Adolescent Schizophrenia Study, Mexico (n = 97). An exploratory factor analysis was performed to investigate the underlying structure of negative symptoms (measured with the Positive and Negative Syndrome Scale (PANSS)). Factor-models were further assessed using confirmatory factor analyses. Associations between negative symptom domains and six cognitive domains were assessed using multiple linear regression models controlling for age, sex and cohort. The neurocognitive domains from the MATRICS Consensus Cognitive Battery included: speed of processing, attention, working memory, verbal learning, visual learning, and reasoning and problem solving. Results: The exploratory factor analysis of PANSS negative symptoms suggested retaining only a single factor, but a forced two factor solution corroborated previously described factors of apathy and diminished expression in adult-onset schizophrenia. Results from confirmatory factor analysis indicated a better fit for the two-factor model than for the one-factor model. For both negative symptom domains, negative symptom scores were inversely associated with verbal learning scores. Conclusion: The results support the presence of two domains of negative symptoms in EOP; apathy and diminished expression. Future studies on negative symptoms in EOP should examine putative differential effects of these symptom domains. For both domains, negative symptom scores were significantly inversely associated with verbal learning.
format Online
Article
Text
id pubmed-8777217
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87772172022-01-22 Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis Mørch-Johnsen, Lynn Smelror, Runar Elle Andreou, Dimitrios Barth, Claudia Johannessen, Cecilie Wedervang-Resell, Kirsten Wortinger, Laura A. Díaz, Ricardo Victoria, Gamaliel Ueland, Torill Andreassen, Ole A. Myhre, Anne M. Rund, Bjørn Rishovd Ulloa, Rosa Elena Agartz, Ingrid Front Psychiatry Psychiatry Background: Early-onset psychosis (EOP) is among the leading causes of disease burden in adolescents. Negative symptoms and cognitive deficits predicts poorer functional outcome. A better understanding of the association between negative symptoms and cognitive impairment may inform theories on underlying mechanisms and elucidate targets for development of new treatments. Two domains of negative symptoms have been described in adult patients with schizophrenia: apathy and diminished expression, however, the factorial structure of negative symptoms has not been investigated in EOP. We aimed to explore the factorial structure of negative symptoms and investigate associations between cognitive performance and negative symptom domains in adolescents with EOP. We hypothesized that (1) two negative symptom factors would be identifiable, and that (2) diminished expression would be more strongly associated with cognitive performance, similar to adult psychosis patients. Methods: Adolescent patients with non-affective EOP (n = 169) were included from three cohorts: Youth-TOP, Norway (n = 45), Early-Onset Study, Norway (n = 27) and Adolescent Schizophrenia Study, Mexico (n = 97). An exploratory factor analysis was performed to investigate the underlying structure of negative symptoms (measured with the Positive and Negative Syndrome Scale (PANSS)). Factor-models were further assessed using confirmatory factor analyses. Associations between negative symptom domains and six cognitive domains were assessed using multiple linear regression models controlling for age, sex and cohort. The neurocognitive domains from the MATRICS Consensus Cognitive Battery included: speed of processing, attention, working memory, verbal learning, visual learning, and reasoning and problem solving. Results: The exploratory factor analysis of PANSS negative symptoms suggested retaining only a single factor, but a forced two factor solution corroborated previously described factors of apathy and diminished expression in adult-onset schizophrenia. Results from confirmatory factor analysis indicated a better fit for the two-factor model than for the one-factor model. For both negative symptom domains, negative symptom scores were inversely associated with verbal learning scores. Conclusion: The results support the presence of two domains of negative symptoms in EOP; apathy and diminished expression. Future studies on negative symptoms in EOP should examine putative differential effects of these symptom domains. For both domains, negative symptom scores were significantly inversely associated with verbal learning. Frontiers Media S.A. 2022-01-07 /pmc/articles/PMC8777217/ /pubmed/35069300 http://dx.doi.org/10.3389/fpsyt.2021.825681 Text en Copyright © 2022 Mørch-Johnsen, Smelror, Andreou, Barth, Johannessen, Wedervang-Resell, Wortinger, Díaz, Victoria, Ueland, Andreassen, Myhre, Rund, Ulloa and Agartz. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Mørch-Johnsen, Lynn
Smelror, Runar Elle
Andreou, Dimitrios
Barth, Claudia
Johannessen, Cecilie
Wedervang-Resell, Kirsten
Wortinger, Laura A.
Díaz, Ricardo
Victoria, Gamaliel
Ueland, Torill
Andreassen, Ole A.
Myhre, Anne M.
Rund, Bjørn Rishovd
Ulloa, Rosa Elena
Agartz, Ingrid
Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis
title Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis
title_full Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis
title_fullStr Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis
title_full_unstemmed Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis
title_short Negative Symptom Domains Are Associated With Verbal Learning in Adolescents With Early Onset Psychosis
title_sort negative symptom domains are associated with verbal learning in adolescents with early onset psychosis
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777217/
https://www.ncbi.nlm.nih.gov/pubmed/35069300
http://dx.doi.org/10.3389/fpsyt.2021.825681
work_keys_str_mv AT mørchjohnsenlynn negativesymptomdomainsareassociatedwithverballearninginadolescentswithearlyonsetpsychosis
AT smelrorrunarelle negativesymptomdomainsareassociatedwithverballearninginadolescentswithearlyonsetpsychosis
AT andreoudimitrios negativesymptomdomainsareassociatedwithverballearninginadolescentswithearlyonsetpsychosis
AT barthclaudia negativesymptomdomainsareassociatedwithverballearninginadolescentswithearlyonsetpsychosis
AT johannessencecilie negativesymptomdomainsareassociatedwithverballearninginadolescentswithearlyonsetpsychosis
AT wedervangresellkirsten negativesymptomdomainsareassociatedwithverballearninginadolescentswithearlyonsetpsychosis
AT wortingerlauraa negativesymptomdomainsareassociatedwithverballearninginadolescentswithearlyonsetpsychosis
AT diazricardo negativesymptomdomainsareassociatedwithverballearninginadolescentswithearlyonsetpsychosis
AT victoriagamaliel negativesymptomdomainsareassociatedwithverballearninginadolescentswithearlyonsetpsychosis
AT uelandtorill negativesymptomdomainsareassociatedwithverballearninginadolescentswithearlyonsetpsychosis
AT andreassenolea negativesymptomdomainsareassociatedwithverballearninginadolescentswithearlyonsetpsychosis
AT myhreannem negativesymptomdomainsareassociatedwithverballearninginadolescentswithearlyonsetpsychosis
AT rundbjørnrishovd negativesymptomdomainsareassociatedwithverballearninginadolescentswithearlyonsetpsychosis
AT ulloarosaelena negativesymptomdomainsareassociatedwithverballearninginadolescentswithearlyonsetpsychosis
AT agartzingrid negativesymptomdomainsareassociatedwithverballearninginadolescentswithearlyonsetpsychosis