Cargando…
Potential bioactive coating system for high-performance absorbable magnesium bone implants
Magnesium alloys are considered the most suitable absorbable metals for bone fracture fixation implants. The main challenge in absorbable magnesium alloys is their high corrosion/degradation rate that needs to be controlled. Various coatings have been applied to magnesium alloys to slow down their c...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777287/ https://www.ncbi.nlm.nih.gov/pubmed/35087962 http://dx.doi.org/10.1016/j.bioactmat.2021.10.034 |
_version_ | 1784637034394025984 |
---|---|
author | Sarian, Murni Nazira Iqbal, Nida Sotoudehbagha, Pedram Razavi, Mehdi Ahmed, Qamar Uddin Sukotjo, Cortino Hermawan, Hendra |
author_facet | Sarian, Murni Nazira Iqbal, Nida Sotoudehbagha, Pedram Razavi, Mehdi Ahmed, Qamar Uddin Sukotjo, Cortino Hermawan, Hendra |
author_sort | Sarian, Murni Nazira |
collection | PubMed |
description | Magnesium alloys are considered the most suitable absorbable metals for bone fracture fixation implants. The main challenge in absorbable magnesium alloys is their high corrosion/degradation rate that needs to be controlled. Various coatings have been applied to magnesium alloys to slow down their corrosion rates to match their corrosion rate to the regeneration rate of the bone fracture. In this review, a bioactive coating is proposed to slow down the corrosion rate of magnesium alloys and accelerate the bone fracture healing process. The main aim of the bioactive coatings is to enhance the direct attachment of living tissues and thereby facilitate osteoconduction. Hydroxyapatite, collagen type I, recombinant human bone morphogenetic proteins 2, simvastatin, zoledronate, and strontium are six bioactive agents that show high potential for developing a bioactive coating system for high-performance absorbable magnesium bone implants. In addition to coating, the substrate itself can be made bioactive by alloying magnesium with calcium, zinc, copper, and manganese that were found to promote bone regeneration. |
format | Online Article Text |
id | pubmed-8777287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-87772872022-01-26 Potential bioactive coating system for high-performance absorbable magnesium bone implants Sarian, Murni Nazira Iqbal, Nida Sotoudehbagha, Pedram Razavi, Mehdi Ahmed, Qamar Uddin Sukotjo, Cortino Hermawan, Hendra Bioact Mater Article Magnesium alloys are considered the most suitable absorbable metals for bone fracture fixation implants. The main challenge in absorbable magnesium alloys is their high corrosion/degradation rate that needs to be controlled. Various coatings have been applied to magnesium alloys to slow down their corrosion rates to match their corrosion rate to the regeneration rate of the bone fracture. In this review, a bioactive coating is proposed to slow down the corrosion rate of magnesium alloys and accelerate the bone fracture healing process. The main aim of the bioactive coatings is to enhance the direct attachment of living tissues and thereby facilitate osteoconduction. Hydroxyapatite, collagen type I, recombinant human bone morphogenetic proteins 2, simvastatin, zoledronate, and strontium are six bioactive agents that show high potential for developing a bioactive coating system for high-performance absorbable magnesium bone implants. In addition to coating, the substrate itself can be made bioactive by alloying magnesium with calcium, zinc, copper, and manganese that were found to promote bone regeneration. KeAi Publishing 2021-10-27 /pmc/articles/PMC8777287/ /pubmed/35087962 http://dx.doi.org/10.1016/j.bioactmat.2021.10.034 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sarian, Murni Nazira Iqbal, Nida Sotoudehbagha, Pedram Razavi, Mehdi Ahmed, Qamar Uddin Sukotjo, Cortino Hermawan, Hendra Potential bioactive coating system for high-performance absorbable magnesium bone implants |
title | Potential bioactive coating system for high-performance absorbable magnesium bone implants |
title_full | Potential bioactive coating system for high-performance absorbable magnesium bone implants |
title_fullStr | Potential bioactive coating system for high-performance absorbable magnesium bone implants |
title_full_unstemmed | Potential bioactive coating system for high-performance absorbable magnesium bone implants |
title_short | Potential bioactive coating system for high-performance absorbable magnesium bone implants |
title_sort | potential bioactive coating system for high-performance absorbable magnesium bone implants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777287/ https://www.ncbi.nlm.nih.gov/pubmed/35087962 http://dx.doi.org/10.1016/j.bioactmat.2021.10.034 |
work_keys_str_mv | AT sarianmurninazira potentialbioactivecoatingsystemforhighperformanceabsorbablemagnesiumboneimplants AT iqbalnida potentialbioactivecoatingsystemforhighperformanceabsorbablemagnesiumboneimplants AT sotoudehbaghapedram potentialbioactivecoatingsystemforhighperformanceabsorbablemagnesiumboneimplants AT razavimehdi potentialbioactivecoatingsystemforhighperformanceabsorbablemagnesiumboneimplants AT ahmedqamaruddin potentialbioactivecoatingsystemforhighperformanceabsorbablemagnesiumboneimplants AT sukotjocortino potentialbioactivecoatingsystemforhighperformanceabsorbablemagnesiumboneimplants AT hermawanhendra potentialbioactivecoatingsystemforhighperformanceabsorbablemagnesiumboneimplants |