Cargando…

Intratumoral gene expression of dihydrofolate reductase and folylpoly-c-glutamate synthetase affects the sensitivity to 5-fluorouracil in non-small cell lung cancer

BACKGROUND: Various factors related to the sensitivity of non-small cell lung carcinoma (NSCLC) to 5-fluorouracil (5-FU) have been reported, and some of them have been clinically applied. In this single-institutional prospective analysis, the mRNA expression level of five folic acid-associated enzym...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sakon, Kayo, Sasaki, Masato, Tanaka, Kaede, Mizunaga, Tae, Yano, Keita, Kawamura, Yuuko, Okada, Akitoshi, Ikeda, Takeshi, Tanabe, Sawaka, Takamori, Atsushi, Yamada, Narihisa, Morioka, Kouichi, Koshiji, Takaaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777502/ https://www.ncbi.nlm.nih.gov/pubmed/35201464 http://dx.doi.org/10.1007/s12672-021-00413-w

Ejemplares similares

Pulmonary valve myxoma requiring pulmonary valve replacement: a case report
por: Tanabe, Sawaka, et al.
Publicado: (2022)

Treatment of anomalous arterial supply to the basal segment of left lung with aortic stent graft
por: Yano, Keita, et al.
Publicado: (2022)

Case of a lung collision tumor consisting of squamous cell carcinoma of the lung and diffuse large B‐cell lymphoma
por: Sasaki, Masato, et al.
Publicado: (2022)

Analysis of folylpoly-γ-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells
por: Leclerc, Guy J, et al.
Publicado: (2006)

The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics
por: A-Elbasit, Ishraga E, et al.
Publicado: (2007)

Evaluation of dihydrofolate reductase and dihydropteroate synthetase genotypes that confer resistance to sulphadoxine-pyrimethamine in Plasmodium falciparum in Haiti
por: Carter, Tamar E, et al.
Publicado: (2012)

Tales of Dihydrofolate Binding to R67 Dihydrofolate Reductase
por: Duff, Michael R., et al.
Publicado: (2015)

Island-wide diversity in single nucleotide polymorphisms of the Plasmodium vivax dihydrofolate reductase and dihydropteroate synthetase genes in Sri Lanka
por: Schousboe, Mette L, et al.
Publicado: (2007)

Geometrical and electrophysiological data of the moving membrane method for the osmotic water permeability of a lipid bilayer
por: Yano, Keita, et al.
Publicado: (2021)

Polymorphisms in Plasmodium falciparum dihydropteroate synthetase and dihydrofolate reductase genes in Nigerian children with uncomplicated malaria using high-resolution melting technique
por: Kayode, Adeyemi T., et al.
Publicado: (2021)

Adaptations for Pressure and Temperature in Dihydrofolate Reductases
por: Penhallurick, Ryan W., et al.
Publicado: (2021)

Frequencies distribution of dihydrofolate reductase and dihydropteroate synthetase mutant alleles associated with sulfadoxine–pyrimethamine resistance in Plasmodium falciparum population from Hadhramout Governorate, Yemen
por: Bamaga, Omar A. A., et al.
Publicado: (2015)

Genetic diversity of the Plasmodium falciparum GTP-cyclohydrolase 1, dihydrofolate reductase and dihydropteroate synthetase genes reveals new insights into sulfadoxine-pyrimethamine antimalarial drug resistance
por: Turkiewicz, Anna, et al.
Publicado: (2020)

Minimization of dynamic effects in the evolution of dihydrofolate reductase
por: Ruiz-Pernía, J. Javier, et al.
Publicado: (2016)

The Combination of Arginine Deprivation and 5-Fluorouracil Improves Therapeutic Efficacy in Argininosuccinate Synthetase Negative Hepatocellular Carcinoma
por: Thongkum, Angkana, et al.
Publicado: (2017)

Binding of Natural and Synthetic Polyphenols to Human Dihydrofolate Reductase
por: Sánchez-del-Campo, Luís, et al.
Publicado: (2009)

The Role of Large-Scale Motions in Catalysis by Dihydrofolate Reductase
por: Loveridge, E. Joel, et al.
Publicado: (2011)

Side Chain Conformational Averaging in Human Dihydrofolate Reductase
por: Tuttle, Lisa M., et al.
Publicado: (2014)

Divergent evolution of protein conformational dynamics in dihydrofolate reductase
por: Bhabha, Gira, et al.
Publicado: (2013)

Evolution Alters the Enzymatic Reaction Coordinate of Dihydrofolate Reductase
por: Masterson, Jean E., et al.
Publicado: (2014)

Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases
por: Luk, Louis Y. P., et al.
Publicado: (2014)

Dihydrofolate Reductase Gene Variations in Susceptibility to Disease and Treatment Outcomes
por: Askari, Bahram S., et al.
Publicado: (2010)

Dihydrofolate reductase as a model for studies of enzyme dynamics and catalysis
por: Kohen, Amnon
Publicado: (2015)

A calibration curve for immobilized dihydrofolate reductase activity assay
por: Singh, Priyanka, et al.
Publicado: (2015)

Lausannevirus Encodes a Functional Dihydrofolate Reductase Susceptible to Proguanil
por: Mueller, L., et al.
Publicado: (2017)

Hypermethylation of dihydrofolate reductase promoter increases the risk of hypertension in Chinese
por: Xu, Guodong, et al.
Publicado: (2020)

Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase
por: Wang, Yinghui, et al.
Publicado: (2021)

Computational Development of Inhibitors of Plasmid-Borne Bacterial Dihydrofolate Reductase
por: Silva, Pedro J.
Publicado: (2022)

UCN‐01 (7‐Hydroxystaurosporine) Enhances 5‐Fluorouracil Cytotoxicity through Down‐regulation of Thymidylate Synthetase Messenger RNA
por: Abe, Sadanori, et al.
Publicado: (2000)

Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase
por: Hawkins, Vivian N, et al.
Publicado: (2008)

Dihydrofolate Reductase I164L Mutation in Plasmodium falciparum, Madagascar
por: Ménard, Didier, et al.
Publicado: (2008)

Computational analysis of binding between malarial dihydrofolate reductases and anti-folates
por: Choowongkomon, Kiattawee, et al.
Publicado: (2010)

Thermal Adaptation of Dihydrofolate Reductase from the Moderate Thermophile Geobacillus stearothermophilus
por: Guo, Jiannan, et al.
Publicado: (2014)

Optimized peptide based inhibitors targeting the dihydrofolate reductase pathway in cancer
por: Singh, Amrinder, et al.
Publicado: (2018)

Molecular Docking Analysis of Pyrimethamine Derivatives with Plasmodium falciparum Dihydrofolate Reductase
por: Singh, Indra Vikram, et al.
Publicado: (2018)

Molecular Characteristics and Serodiagnostic Potential of Dihydrofolate Reductase from Echinococcus granulosus
por: Song, Xingju, et al.
Publicado: (2017)

A comparative molecular docking study of curcumin and methotrexate to dihydrofolate reductase
por: Hobani, Yahya, et al.
Publicado: (2017)

Dihydrofolate Reductase Inhibitors: The Pharmacophore as a Guide for Co-Crystal Screening
por: Baptista, João A., et al.
Publicado: (2021)

Cryo‐kinetics Reveal Dynamic Effects on the Chemistry of Human Dihydrofolate Reductase
por: Adesina, Aduragbemi S., et al.
Publicado: (2021)

Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases
por: Santucci, Matteo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_s4q374rnbqmeuf3k7n7i8kfs96