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The effect of intraperitoneal administration of BromAc on blood parameters: phase 1 study

Intraperitoneal administration of BromAc (bromelain + acetylcysteine) is currently undergoing a phase 1 clinical trial for pseudomyxoma peritonei at our institution. This study reports on analysis of routine blood parameters before and after treatment for a series of 25 patients in this trial. Blood...

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Autores principales: Ke, Kevin, Pillai, Krishna, Mekkawy, Ahmed H., Akhter, Javed, Badar, Samina, Valle, Sarah J., Morris, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777505/
https://www.ncbi.nlm.nih.gov/pubmed/35201475
http://dx.doi.org/10.1007/s12672-021-00418-5
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author Ke, Kevin
Pillai, Krishna
Mekkawy, Ahmed H.
Akhter, Javed
Badar, Samina
Valle, Sarah J.
Morris, David L.
author_facet Ke, Kevin
Pillai, Krishna
Mekkawy, Ahmed H.
Akhter, Javed
Badar, Samina
Valle, Sarah J.
Morris, David L.
author_sort Ke, Kevin
collection PubMed
description Intraperitoneal administration of BromAc (bromelain + acetylcysteine) is currently undergoing a phase 1 clinical trial for pseudomyxoma peritonei at our institution. This study reports on analysis of routine blood parameters before and after treatment for a series of 25 patients in this trial. Blood parameters assessed included full blood count, electrolytes, urea, and creatinine, liver function tests, coagulation studies, as well as inflammatory markers (CRP). Certain parameters such as CRP, and white cell count, were significantly elevated after treatment whilst serum albumin level was reduced indicating an inflammatory reaction. However, liver enzymes, coagulation studies, and other parameters were not affected. Therefore, there are no additional safety signals evident upon analysis of routine blood parameter testing.
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spelling pubmed-87775052022-02-03 The effect of intraperitoneal administration of BromAc on blood parameters: phase 1 study Ke, Kevin Pillai, Krishna Mekkawy, Ahmed H. Akhter, Javed Badar, Samina Valle, Sarah J. Morris, David L. Discov Oncol Research Intraperitoneal administration of BromAc (bromelain + acetylcysteine) is currently undergoing a phase 1 clinical trial for pseudomyxoma peritonei at our institution. This study reports on analysis of routine blood parameters before and after treatment for a series of 25 patients in this trial. Blood parameters assessed included full blood count, electrolytes, urea, and creatinine, liver function tests, coagulation studies, as well as inflammatory markers (CRP). Certain parameters such as CRP, and white cell count, were significantly elevated after treatment whilst serum albumin level was reduced indicating an inflammatory reaction. However, liver enzymes, coagulation studies, and other parameters were not affected. Therefore, there are no additional safety signals evident upon analysis of routine blood parameter testing. Springer US 2021-08-16 /pmc/articles/PMC8777505/ /pubmed/35201475 http://dx.doi.org/10.1007/s12672-021-00418-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Ke, Kevin
Pillai, Krishna
Mekkawy, Ahmed H.
Akhter, Javed
Badar, Samina
Valle, Sarah J.
Morris, David L.
The effect of intraperitoneal administration of BromAc on blood parameters: phase 1 study
title The effect of intraperitoneal administration of BromAc on blood parameters: phase 1 study
title_full The effect of intraperitoneal administration of BromAc on blood parameters: phase 1 study
title_fullStr The effect of intraperitoneal administration of BromAc on blood parameters: phase 1 study
title_full_unstemmed The effect of intraperitoneal administration of BromAc on blood parameters: phase 1 study
title_short The effect of intraperitoneal administration of BromAc on blood parameters: phase 1 study
title_sort effect of intraperitoneal administration of bromac on blood parameters: phase 1 study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777505/
https://www.ncbi.nlm.nih.gov/pubmed/35201475
http://dx.doi.org/10.1007/s12672-021-00418-5
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