Tamoxifen and oxidative stress: an overlooked connection

Tamoxifen is the gold standard drug for the treatment of breast cancer in pre and post-menopausal women. Its journey from a failing contraceptive to a blockbuster is an example of pharmaceutical innovation challenges. Tamoxifen has a wide range of pharmacological activities; a drug that was initiall...

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Autores principales: Ahmed, Nermin S., Samec, Marek, Liskova, Alena, Kubatka, Peter, Saso, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777555/
https://www.ncbi.nlm.nih.gov/pubmed/35201439
http://dx.doi.org/10.1007/s12672-021-00411-y
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author Ahmed, Nermin S.
Samec, Marek
Liskova, Alena
Kubatka, Peter
Saso, Luciano
author_facet Ahmed, Nermin S.
Samec, Marek
Liskova, Alena
Kubatka, Peter
Saso, Luciano
author_sort Ahmed, Nermin S.
collection PubMed
description Tamoxifen is the gold standard drug for the treatment of breast cancer in pre and post-menopausal women. Its journey from a failing contraceptive to a blockbuster is an example of pharmaceutical innovation challenges. Tamoxifen has a wide range of pharmacological activities; a drug that was initially thought to work via a simple Estrogen receptor (ER) mechanism was proven to mediate its activity through several non-ER mechanisms. Here in we review the previous literature describing ER and non-ER targets of tamoxifen, we highlighted the overlooked connection between tamoxifen, tamoxifen apoptotic effects and oxidative stress.
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spelling pubmed-87775552022-02-03 Tamoxifen and oxidative stress: an overlooked connection Ahmed, Nermin S. Samec, Marek Liskova, Alena Kubatka, Peter Saso, Luciano Discov Oncol Review Tamoxifen is the gold standard drug for the treatment of breast cancer in pre and post-menopausal women. Its journey from a failing contraceptive to a blockbuster is an example of pharmaceutical innovation challenges. Tamoxifen has a wide range of pharmacological activities; a drug that was initially thought to work via a simple Estrogen receptor (ER) mechanism was proven to mediate its activity through several non-ER mechanisms. Here in we review the previous literature describing ER and non-ER targets of tamoxifen, we highlighted the overlooked connection between tamoxifen, tamoxifen apoptotic effects and oxidative stress. Springer US 2021-05-27 /pmc/articles/PMC8777555/ /pubmed/35201439 http://dx.doi.org/10.1007/s12672-021-00411-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Ahmed, Nermin S.
Samec, Marek
Liskova, Alena
Kubatka, Peter
Saso, Luciano
Tamoxifen and oxidative stress: an overlooked connection
title Tamoxifen and oxidative stress: an overlooked connection
title_full Tamoxifen and oxidative stress: an overlooked connection
title_fullStr Tamoxifen and oxidative stress: an overlooked connection
title_full_unstemmed Tamoxifen and oxidative stress: an overlooked connection
title_short Tamoxifen and oxidative stress: an overlooked connection
title_sort tamoxifen and oxidative stress: an overlooked connection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777555/
https://www.ncbi.nlm.nih.gov/pubmed/35201439
http://dx.doi.org/10.1007/s12672-021-00411-y
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