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The Impact of Head Model Choice on the In Vitro Evaluation of Aerosol Drug Delivery

There are variations in the values reported for aerosol drug delivery across in vitro experiments throughout the published literature, and often with the same devices or similar experimental setups. Factors contributing to this variability include, but are not limited to device type, equipment setti...

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Autores principales: Gallagher, Lauren, Joyce, Mary, Murphy, Barry, Mac Giolla Eain, Marc, MacLoughlin, Ronan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777612/
https://www.ncbi.nlm.nih.gov/pubmed/35056920
http://dx.doi.org/10.3390/pharmaceutics14010024
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author Gallagher, Lauren
Joyce, Mary
Murphy, Barry
Mac Giolla Eain, Marc
MacLoughlin, Ronan
author_facet Gallagher, Lauren
Joyce, Mary
Murphy, Barry
Mac Giolla Eain, Marc
MacLoughlin, Ronan
author_sort Gallagher, Lauren
collection PubMed
description There are variations in the values reported for aerosol drug delivery across in vitro experiments throughout the published literature, and often with the same devices or similar experimental setups. Factors contributing to this variability include, but are not limited to device type, equipment settings, drug type and quantification methods. This study assessed the impact of head model choice on aerosol drug delivery using six different adults and three different paediatric head models in combination with a facemask, mouthpiece, and high-flow nasal cannula. Under controlled test conditions, the quantity of drug collected varied depending on the choice of head model. Head models vary depending on a combination of structural design differences, facial features (size and structure), internal volume measurements and airway geometries and these variations result in the differences in aerosol delivery. Of the widely available head models used in this study, only three were seen to closely predict in vivo aerosol delivery performance in adults compared with published scintigraphy data. Further, this testing identified the limited utility of some head models under certain test conditions, for example, the range reported across head models was aerosol drug delivery of 2.62 ± 2.86% to 37.79 ± 1.55% when used with a facemask. For the first time, this study highlights the impact of head model choice on reported aerosol drug delivery within a laboratory setting and contributes to explaining the differences in values reported within the literature.
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spelling pubmed-87776122022-01-22 The Impact of Head Model Choice on the In Vitro Evaluation of Aerosol Drug Delivery Gallagher, Lauren Joyce, Mary Murphy, Barry Mac Giolla Eain, Marc MacLoughlin, Ronan Pharmaceutics Article There are variations in the values reported for aerosol drug delivery across in vitro experiments throughout the published literature, and often with the same devices or similar experimental setups. Factors contributing to this variability include, but are not limited to device type, equipment settings, drug type and quantification methods. This study assessed the impact of head model choice on aerosol drug delivery using six different adults and three different paediatric head models in combination with a facemask, mouthpiece, and high-flow nasal cannula. Under controlled test conditions, the quantity of drug collected varied depending on the choice of head model. Head models vary depending on a combination of structural design differences, facial features (size and structure), internal volume measurements and airway geometries and these variations result in the differences in aerosol delivery. Of the widely available head models used in this study, only three were seen to closely predict in vivo aerosol delivery performance in adults compared with published scintigraphy data. Further, this testing identified the limited utility of some head models under certain test conditions, for example, the range reported across head models was aerosol drug delivery of 2.62 ± 2.86% to 37.79 ± 1.55% when used with a facemask. For the first time, this study highlights the impact of head model choice on reported aerosol drug delivery within a laboratory setting and contributes to explaining the differences in values reported within the literature. MDPI 2021-12-23 /pmc/articles/PMC8777612/ /pubmed/35056920 http://dx.doi.org/10.3390/pharmaceutics14010024 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gallagher, Lauren
Joyce, Mary
Murphy, Barry
Mac Giolla Eain, Marc
MacLoughlin, Ronan
The Impact of Head Model Choice on the In Vitro Evaluation of Aerosol Drug Delivery
title The Impact of Head Model Choice on the In Vitro Evaluation of Aerosol Drug Delivery
title_full The Impact of Head Model Choice on the In Vitro Evaluation of Aerosol Drug Delivery
title_fullStr The Impact of Head Model Choice on the In Vitro Evaluation of Aerosol Drug Delivery
title_full_unstemmed The Impact of Head Model Choice on the In Vitro Evaluation of Aerosol Drug Delivery
title_short The Impact of Head Model Choice on the In Vitro Evaluation of Aerosol Drug Delivery
title_sort impact of head model choice on the in vitro evaluation of aerosol drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777612/
https://www.ncbi.nlm.nih.gov/pubmed/35056920
http://dx.doi.org/10.3390/pharmaceutics14010024
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