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Gut Microbiome Profiles in Colonizations with the Enteric Protozoa Blastocystis in Korean Populations
The influence of unicellular eukaryotic microorganisms on human gut health and disease is largely unexplored. Blastocystis species commonly colonize the gut, but their clinical significance and ecological role are unclear. We evaluated the effect of Blastocystis colonization on the fecal microbiota...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777631/ https://www.ncbi.nlm.nih.gov/pubmed/35056483 http://dx.doi.org/10.3390/microorganisms10010034 |
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author | Kim, Moon-Ju Lee, Yu Jeong Kim, Tae-Jong Won, Eun Jeong |
author_facet | Kim, Moon-Ju Lee, Yu Jeong Kim, Tae-Jong Won, Eun Jeong |
author_sort | Kim, Moon-Ju |
collection | PubMed |
description | The influence of unicellular eukaryotic microorganisms on human gut health and disease is largely unexplored. Blastocystis species commonly colonize the gut, but their clinical significance and ecological role are unclear. We evaluated the effect of Blastocystis colonization on the fecal microbiota of Koreans. In total, 39 Blastocystis-positive and -negative fecal samples were analyzed. The fecal microbiome was assessed by targeting the V3–V4 region of the bacterial 16S ribosomal gene. Bacterial diversity was greater in the Blastocystis-positive than in the Blastocystis-negative group. The bacterial community structure and phylogenetic diversity differed according to the presence of Blastocystis. The mean proportions of Faecalibacterium species and Ruminococcaceae were larger in the Blastocystis-positive group, and that of Enterococcus species was larger in the Blastocystis-negative group. Linear discriminant analysis showed that Faecalibacterium, Prevotella 9, Ruminococcaceae UCG-002, Muribaculaceae, Rikenellaceae, Acidaminococcaceae, Phascolarctobacterium, and Ruminococcaceae UCG-005 were highly enriched in the Blastocystis-positive group, whereas Enterococcus hirae, Enterococcus faecalis, Enterococcus durans, Enterococcaceae, Lactobacillales, and Bacilli were highly abundant in the Blastocystis-negative group. Overall, our results enlighten the notion that Blastocystis colonization is associated with a healthy gut microbiota. |
format | Online Article Text |
id | pubmed-8777631 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87776312022-01-22 Gut Microbiome Profiles in Colonizations with the Enteric Protozoa Blastocystis in Korean Populations Kim, Moon-Ju Lee, Yu Jeong Kim, Tae-Jong Won, Eun Jeong Microorganisms Brief Report The influence of unicellular eukaryotic microorganisms on human gut health and disease is largely unexplored. Blastocystis species commonly colonize the gut, but their clinical significance and ecological role are unclear. We evaluated the effect of Blastocystis colonization on the fecal microbiota of Koreans. In total, 39 Blastocystis-positive and -negative fecal samples were analyzed. The fecal microbiome was assessed by targeting the V3–V4 region of the bacterial 16S ribosomal gene. Bacterial diversity was greater in the Blastocystis-positive than in the Blastocystis-negative group. The bacterial community structure and phylogenetic diversity differed according to the presence of Blastocystis. The mean proportions of Faecalibacterium species and Ruminococcaceae were larger in the Blastocystis-positive group, and that of Enterococcus species was larger in the Blastocystis-negative group. Linear discriminant analysis showed that Faecalibacterium, Prevotella 9, Ruminococcaceae UCG-002, Muribaculaceae, Rikenellaceae, Acidaminococcaceae, Phascolarctobacterium, and Ruminococcaceae UCG-005 were highly enriched in the Blastocystis-positive group, whereas Enterococcus hirae, Enterococcus faecalis, Enterococcus durans, Enterococcaceae, Lactobacillales, and Bacilli were highly abundant in the Blastocystis-negative group. Overall, our results enlighten the notion that Blastocystis colonization is associated with a healthy gut microbiota. MDPI 2021-12-24 /pmc/articles/PMC8777631/ /pubmed/35056483 http://dx.doi.org/10.3390/microorganisms10010034 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Kim, Moon-Ju Lee, Yu Jeong Kim, Tae-Jong Won, Eun Jeong Gut Microbiome Profiles in Colonizations with the Enteric Protozoa Blastocystis in Korean Populations |
title | Gut Microbiome Profiles in Colonizations with the Enteric Protozoa Blastocystis in Korean Populations |
title_full | Gut Microbiome Profiles in Colonizations with the Enteric Protozoa Blastocystis in Korean Populations |
title_fullStr | Gut Microbiome Profiles in Colonizations with the Enteric Protozoa Blastocystis in Korean Populations |
title_full_unstemmed | Gut Microbiome Profiles in Colonizations with the Enteric Protozoa Blastocystis in Korean Populations |
title_short | Gut Microbiome Profiles in Colonizations with the Enteric Protozoa Blastocystis in Korean Populations |
title_sort | gut microbiome profiles in colonizations with the enteric protozoa blastocystis in korean populations |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777631/ https://www.ncbi.nlm.nih.gov/pubmed/35056483 http://dx.doi.org/10.3390/microorganisms10010034 |
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