Real-Time Optimization of Pharmacodynamic Target Attainment at Infection Site during Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Gram Negatives with Ceftazidime–Avibactam-Based Regimens: A Report of Two Cases

We present two cases of post-neurosurgical ventriculitis caused by carbapenem-resistant Gram-negative pathogens successfully treated with high-dose ceftazidime/avibactam. The existence of a real-time clinical pharmacological advice program, by enabling the optimization of the PK/PD targets over time...

Descripción completa

Detalles Bibliográficos
Autores principales: Gatti, Milo, Virgili, Giulio, Cojutti, Pier Giorgio, Gaibani, Paolo, Conti, Matteo, Sturiale, Carmelo, Pea, Federico, Viale, Pierluigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777709/
https://www.ncbi.nlm.nih.gov/pubmed/35056602
http://dx.doi.org/10.3390/microorganisms10010154
_version_ 1784637132014354432
author Gatti, Milo
Virgili, Giulio
Cojutti, Pier Giorgio
Gaibani, Paolo
Conti, Matteo
Sturiale, Carmelo
Pea, Federico
Viale, Pierluigi
author_facet Gatti, Milo
Virgili, Giulio
Cojutti, Pier Giorgio
Gaibani, Paolo
Conti, Matteo
Sturiale, Carmelo
Pea, Federico
Viale, Pierluigi
author_sort Gatti, Milo
collection PubMed
description We present two cases of post-neurosurgical ventriculitis caused by carbapenem-resistant Gram-negative pathogens successfully treated with high-dose ceftazidime/avibactam. The existence of a real-time clinical pharmacological advice program, by enabling the optimization of the PK/PD targets over time at the infection site, turned out to be very helpful.
format Online
Article
Text
id pubmed-8777709
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87777092022-01-22 Real-Time Optimization of Pharmacodynamic Target Attainment at Infection Site during Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Gram Negatives with Ceftazidime–Avibactam-Based Regimens: A Report of Two Cases Gatti, Milo Virgili, Giulio Cojutti, Pier Giorgio Gaibani, Paolo Conti, Matteo Sturiale, Carmelo Pea, Federico Viale, Pierluigi Microorganisms Case Report We present two cases of post-neurosurgical ventriculitis caused by carbapenem-resistant Gram-negative pathogens successfully treated with high-dose ceftazidime/avibactam. The existence of a real-time clinical pharmacological advice program, by enabling the optimization of the PK/PD targets over time at the infection site, turned out to be very helpful. MDPI 2022-01-12 /pmc/articles/PMC8777709/ /pubmed/35056602 http://dx.doi.org/10.3390/microorganisms10010154 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Gatti, Milo
Virgili, Giulio
Cojutti, Pier Giorgio
Gaibani, Paolo
Conti, Matteo
Sturiale, Carmelo
Pea, Federico
Viale, Pierluigi
Real-Time Optimization of Pharmacodynamic Target Attainment at Infection Site during Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Gram Negatives with Ceftazidime–Avibactam-Based Regimens: A Report of Two Cases
title Real-Time Optimization of Pharmacodynamic Target Attainment at Infection Site during Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Gram Negatives with Ceftazidime–Avibactam-Based Regimens: A Report of Two Cases
title_full Real-Time Optimization of Pharmacodynamic Target Attainment at Infection Site during Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Gram Negatives with Ceftazidime–Avibactam-Based Regimens: A Report of Two Cases
title_fullStr Real-Time Optimization of Pharmacodynamic Target Attainment at Infection Site during Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Gram Negatives with Ceftazidime–Avibactam-Based Regimens: A Report of Two Cases
title_full_unstemmed Real-Time Optimization of Pharmacodynamic Target Attainment at Infection Site during Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Gram Negatives with Ceftazidime–Avibactam-Based Regimens: A Report of Two Cases
title_short Real-Time Optimization of Pharmacodynamic Target Attainment at Infection Site during Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Gram Negatives with Ceftazidime–Avibactam-Based Regimens: A Report of Two Cases
title_sort real-time optimization of pharmacodynamic target attainment at infection site during treatment of post-neurosurgical ventriculitis caused by carbapenem-resistant gram negatives with ceftazidime–avibactam-based regimens: a report of two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777709/
https://www.ncbi.nlm.nih.gov/pubmed/35056602
http://dx.doi.org/10.3390/microorganisms10010154
work_keys_str_mv AT gattimilo realtimeoptimizationofpharmacodynamictargetattainmentatinfectionsiteduringtreatmentofpostneurosurgicalventriculitiscausedbycarbapenemresistantgramnegativeswithceftazidimeavibactambasedregimensareportoftwocases
AT virgiligiulio realtimeoptimizationofpharmacodynamictargetattainmentatinfectionsiteduringtreatmentofpostneurosurgicalventriculitiscausedbycarbapenemresistantgramnegativeswithceftazidimeavibactambasedregimensareportoftwocases
AT cojuttipiergiorgio realtimeoptimizationofpharmacodynamictargetattainmentatinfectionsiteduringtreatmentofpostneurosurgicalventriculitiscausedbycarbapenemresistantgramnegativeswithceftazidimeavibactambasedregimensareportoftwocases
AT gaibanipaolo realtimeoptimizationofpharmacodynamictargetattainmentatinfectionsiteduringtreatmentofpostneurosurgicalventriculitiscausedbycarbapenemresistantgramnegativeswithceftazidimeavibactambasedregimensareportoftwocases
AT contimatteo realtimeoptimizationofpharmacodynamictargetattainmentatinfectionsiteduringtreatmentofpostneurosurgicalventriculitiscausedbycarbapenemresistantgramnegativeswithceftazidimeavibactambasedregimensareportoftwocases
AT sturialecarmelo realtimeoptimizationofpharmacodynamictargetattainmentatinfectionsiteduringtreatmentofpostneurosurgicalventriculitiscausedbycarbapenemresistantgramnegativeswithceftazidimeavibactambasedregimensareportoftwocases
AT peafederico realtimeoptimizationofpharmacodynamictargetattainmentatinfectionsiteduringtreatmentofpostneurosurgicalventriculitiscausedbycarbapenemresistantgramnegativeswithceftazidimeavibactambasedregimensareportoftwocases
AT vialepierluigi realtimeoptimizationofpharmacodynamictargetattainmentatinfectionsiteduringtreatmentofpostneurosurgicalventriculitiscausedbycarbapenemresistantgramnegativeswithceftazidimeavibactambasedregimensareportoftwocases

Ejemplares similares