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Design, Synthesis, Biological Evaluation, and Molecular Modeling of 2-Difluoromethylbenzimidazole Derivatives as Potential PI3Kα Inhibitors

PI3Kα is one of the potential targets for novel anticancer drugs. In this study, a series of 2-difluoromethylbenzimidazole derivatives were studied based on the combination of molecular modeling techniques 3D-QSAR, molecular docking, and molecular dynamics. The results showed that the best comparati...

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Detalles Bibliográficos
Autores principales:	Wang, Xiangcong, Zhang, Moxuan, Zhu, Ranran, Wu, Zhongshan, Wu, Fanhong, Wang, Zhonghua, Yu, Yanyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777764/ https://www.ncbi.nlm.nih.gov/pubmed/35056702 http://dx.doi.org/10.3390/molecules27020387

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