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Effects of Pre-Term Birth on the Cardio-Respiratory Responses to Hypoxic Exercise in Children

Pre-term birth is associated with numerous cardio-respiratory sequelae in children. Whether these impairments impact the responses to exercise in normoxia or hypoxia remains to be established. Fourteen prematurely-born (PREM) (Mean ± SD; gestational age 29 ± 2 weeks; age 9.5 ± 0.3 years), and 15 ful...

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Autores principales: Narang, Benjamin J., Manferdelli, Giorgio, Kepic, Katja, Sotiridis, Alexandros, Osredkar, Damjan, Bourdillon, Nicolas, Millet, Grégoire P., Debevec, Tadej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777779/
https://www.ncbi.nlm.nih.gov/pubmed/35054472
http://dx.doi.org/10.3390/life12010079
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author Narang, Benjamin J.
Manferdelli, Giorgio
Kepic, Katja
Sotiridis, Alexandros
Osredkar, Damjan
Bourdillon, Nicolas
Millet, Grégoire P.
Debevec, Tadej
author_facet Narang, Benjamin J.
Manferdelli, Giorgio
Kepic, Katja
Sotiridis, Alexandros
Osredkar, Damjan
Bourdillon, Nicolas
Millet, Grégoire P.
Debevec, Tadej
author_sort Narang, Benjamin J.
collection PubMed
description Pre-term birth is associated with numerous cardio-respiratory sequelae in children. Whether these impairments impact the responses to exercise in normoxia or hypoxia remains to be established. Fourteen prematurely-born (PREM) (Mean ± SD; gestational age 29 ± 2 weeks; age 9.5 ± 0.3 years), and 15 full-term children (CONT) (gestational age 39 ± 1 weeks; age 9.7 ± 0.9 years), underwent incremental exercise tests to exhaustion in normoxia (FiO(2) = 20.9%) and normobaric hypoxia (FiO(2) = 13.2%) on a cycle ergometer. Cardio-respiratory variables were measured throughout. Peak power output was higher in normoxia than hypoxia (103 ± 17 vs. 77 ± 18 W; p < 0.001), with no difference between CONT and PREM (94 ± 23 vs. 86 ± 19 W; p = 0.154). VO(2)peak was higher in normoxia than hypoxia in CONT (50.8 ± 7.2 vs. 43.8 ± 9.9 mL·kg(−1)·min(−1); p < 0.001) but not in PREM (48.1 ± 7.5 vs. 45.0 ± 6.8 mL·kg(−1)·min(−1); p = 0.137; interaction p = 0.044). Higher peak heart rate (187 ± 11 vs. 180 ± 10 bpm; p = 0.005) and lower stroke volume (72 ± 13 vs. 77 ± 14 mL; p = 0.004) were observed in normoxia versus hypoxia in CONT, with no such differences in PREM (p = 0.218 and >0.999, respectively). In conclusion, premature birth does not appear to exacerbate the negative effect of hypoxia on exercise capacity in children. Further research is warranted to identify whether prematurity elicits a protective effect, and to clarify the potential underlying mechanisms.
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spelling pubmed-87777792022-01-22 Effects of Pre-Term Birth on the Cardio-Respiratory Responses to Hypoxic Exercise in Children Narang, Benjamin J. Manferdelli, Giorgio Kepic, Katja Sotiridis, Alexandros Osredkar, Damjan Bourdillon, Nicolas Millet, Grégoire P. Debevec, Tadej Life (Basel) Article Pre-term birth is associated with numerous cardio-respiratory sequelae in children. Whether these impairments impact the responses to exercise in normoxia or hypoxia remains to be established. Fourteen prematurely-born (PREM) (Mean ± SD; gestational age 29 ± 2 weeks; age 9.5 ± 0.3 years), and 15 full-term children (CONT) (gestational age 39 ± 1 weeks; age 9.7 ± 0.9 years), underwent incremental exercise tests to exhaustion in normoxia (FiO(2) = 20.9%) and normobaric hypoxia (FiO(2) = 13.2%) on a cycle ergometer. Cardio-respiratory variables were measured throughout. Peak power output was higher in normoxia than hypoxia (103 ± 17 vs. 77 ± 18 W; p < 0.001), with no difference between CONT and PREM (94 ± 23 vs. 86 ± 19 W; p = 0.154). VO(2)peak was higher in normoxia than hypoxia in CONT (50.8 ± 7.2 vs. 43.8 ± 9.9 mL·kg(−1)·min(−1); p < 0.001) but not in PREM (48.1 ± 7.5 vs. 45.0 ± 6.8 mL·kg(−1)·min(−1); p = 0.137; interaction p = 0.044). Higher peak heart rate (187 ± 11 vs. 180 ± 10 bpm; p = 0.005) and lower stroke volume (72 ± 13 vs. 77 ± 14 mL; p = 0.004) were observed in normoxia versus hypoxia in CONT, with no such differences in PREM (p = 0.218 and >0.999, respectively). In conclusion, premature birth does not appear to exacerbate the negative effect of hypoxia on exercise capacity in children. Further research is warranted to identify whether prematurity elicits a protective effect, and to clarify the potential underlying mechanisms. MDPI 2022-01-06 /pmc/articles/PMC8777779/ /pubmed/35054472 http://dx.doi.org/10.3390/life12010079 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Narang, Benjamin J.
Manferdelli, Giorgio
Kepic, Katja
Sotiridis, Alexandros
Osredkar, Damjan
Bourdillon, Nicolas
Millet, Grégoire P.
Debevec, Tadej
Effects of Pre-Term Birth on the Cardio-Respiratory Responses to Hypoxic Exercise in Children
title Effects of Pre-Term Birth on the Cardio-Respiratory Responses to Hypoxic Exercise in Children
title_full Effects of Pre-Term Birth on the Cardio-Respiratory Responses to Hypoxic Exercise in Children
title_fullStr Effects of Pre-Term Birth on the Cardio-Respiratory Responses to Hypoxic Exercise in Children
title_full_unstemmed Effects of Pre-Term Birth on the Cardio-Respiratory Responses to Hypoxic Exercise in Children
title_short Effects of Pre-Term Birth on the Cardio-Respiratory Responses to Hypoxic Exercise in Children
title_sort effects of pre-term birth on the cardio-respiratory responses to hypoxic exercise in children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777779/
https://www.ncbi.nlm.nih.gov/pubmed/35054472
http://dx.doi.org/10.3390/life12010079
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