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The Effectiveness of a Diverse COVID-19 Vaccine Portfolio and Its Impact on the Persistence of Positivity and Length of Hospital Stays: The Veneto Region’s Experience

The vaccination campaign for the Veneto region (northeastern Italy) started on 27 December 2020. As of early December 2021, 75.1% of the whole Veneto population has been fully vaccinated. Vaccine efficacy has been demonstrated in many clinical trials, but reports on real-world contexts are still nec...

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Autores principales: Cocchio, Silvia, Zabeo, Federico, Facchin, Giacomo, Piva, Nicolò, Furlan, Patrizia, Nicoletti, Michele, Saia, Mario, Tonon, Michele, Mongillo, Michele, Russo, Francesca, Baldo, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777781/
https://www.ncbi.nlm.nih.gov/pubmed/35062767
http://dx.doi.org/10.3390/vaccines10010107
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author Cocchio, Silvia
Zabeo, Federico
Facchin, Giacomo
Piva, Nicolò
Furlan, Patrizia
Nicoletti, Michele
Saia, Mario
Tonon, Michele
Mongillo, Michele
Russo, Francesca
Baldo, Vincenzo
author_facet Cocchio, Silvia
Zabeo, Federico
Facchin, Giacomo
Piva, Nicolò
Furlan, Patrizia
Nicoletti, Michele
Saia, Mario
Tonon, Michele
Mongillo, Michele
Russo, Francesca
Baldo, Vincenzo
author_sort Cocchio, Silvia
collection PubMed
description The vaccination campaign for the Veneto region (northeastern Italy) started on 27 December 2020. As of early December 2021, 75.1% of the whole Veneto population has been fully vaccinated. Vaccine efficacy has been demonstrated in many clinical trials, but reports on real-world contexts are still necessary. We conducted a retrospective cohort study on 2,233,399 residents in the Veneto region to assess the reduction in the COVID-19 burden, taking different outcomes into consideration. First, we adopted a non-brand-specific approach borrowed from survival analysis to estimate the effectiveness of vaccination against SARS-CoV-2 in preventing infections, hospitalizations, and deaths. We used t-tests and multivariate regressions to examine vaccine impact on breakthrough infections, in terms of the persistence of positivity and the length of hospital stays. Evidence emerging from this study suggests that unvaccinated individuals are significantly more likely to become infected, need hospitalization, and are at a higher risk of death from COVID-19 than those given at least one dose of vaccine. Cox models indicate that the effectiveness of full vaccination is 88% against infection, 94% against hospitalization, and 95% against death. Multivariate regressions suggest that vaccination is significantly correlated with a shorter period of positivity and shorter hospital stays, with each step toward completion of the vaccination cycle coinciding with a reduction of 3.3 days in the persistence of positivity and 2.3 days in the length of hospital stay.
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spelling pubmed-87777812022-01-22 The Effectiveness of a Diverse COVID-19 Vaccine Portfolio and Its Impact on the Persistence of Positivity and Length of Hospital Stays: The Veneto Region’s Experience Cocchio, Silvia Zabeo, Federico Facchin, Giacomo Piva, Nicolò Furlan, Patrizia Nicoletti, Michele Saia, Mario Tonon, Michele Mongillo, Michele Russo, Francesca Baldo, Vincenzo Vaccines (Basel) Article The vaccination campaign for the Veneto region (northeastern Italy) started on 27 December 2020. As of early December 2021, 75.1% of the whole Veneto population has been fully vaccinated. Vaccine efficacy has been demonstrated in many clinical trials, but reports on real-world contexts are still necessary. We conducted a retrospective cohort study on 2,233,399 residents in the Veneto region to assess the reduction in the COVID-19 burden, taking different outcomes into consideration. First, we adopted a non-brand-specific approach borrowed from survival analysis to estimate the effectiveness of vaccination against SARS-CoV-2 in preventing infections, hospitalizations, and deaths. We used t-tests and multivariate regressions to examine vaccine impact on breakthrough infections, in terms of the persistence of positivity and the length of hospital stays. Evidence emerging from this study suggests that unvaccinated individuals are significantly more likely to become infected, need hospitalization, and are at a higher risk of death from COVID-19 than those given at least one dose of vaccine. Cox models indicate that the effectiveness of full vaccination is 88% against infection, 94% against hospitalization, and 95% against death. Multivariate regressions suggest that vaccination is significantly correlated with a shorter period of positivity and shorter hospital stays, with each step toward completion of the vaccination cycle coinciding with a reduction of 3.3 days in the persistence of positivity and 2.3 days in the length of hospital stay. MDPI 2022-01-11 /pmc/articles/PMC8777781/ /pubmed/35062767 http://dx.doi.org/10.3390/vaccines10010107 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cocchio, Silvia
Zabeo, Federico
Facchin, Giacomo
Piva, Nicolò
Furlan, Patrizia
Nicoletti, Michele
Saia, Mario
Tonon, Michele
Mongillo, Michele
Russo, Francesca
Baldo, Vincenzo
The Effectiveness of a Diverse COVID-19 Vaccine Portfolio and Its Impact on the Persistence of Positivity and Length of Hospital Stays: The Veneto Region’s Experience
title The Effectiveness of a Diverse COVID-19 Vaccine Portfolio and Its Impact on the Persistence of Positivity and Length of Hospital Stays: The Veneto Region’s Experience
title_full The Effectiveness of a Diverse COVID-19 Vaccine Portfolio and Its Impact on the Persistence of Positivity and Length of Hospital Stays: The Veneto Region’s Experience
title_fullStr The Effectiveness of a Diverse COVID-19 Vaccine Portfolio and Its Impact on the Persistence of Positivity and Length of Hospital Stays: The Veneto Region’s Experience
title_full_unstemmed The Effectiveness of a Diverse COVID-19 Vaccine Portfolio and Its Impact on the Persistence of Positivity and Length of Hospital Stays: The Veneto Region’s Experience
title_short The Effectiveness of a Diverse COVID-19 Vaccine Portfolio and Its Impact on the Persistence of Positivity and Length of Hospital Stays: The Veneto Region’s Experience
title_sort effectiveness of a diverse covid-19 vaccine portfolio and its impact on the persistence of positivity and length of hospital stays: the veneto region’s experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777781/
https://www.ncbi.nlm.nih.gov/pubmed/35062767
http://dx.doi.org/10.3390/vaccines10010107
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