Cargando…

Anti-α-Glucosidase and Antiglycation Activities of α-Mangostin and New Xanthenone Derivatives: Enzymatic Kinetics and Mechanistic Insights through In Vitro Studies

Diabetes mellitus is characterized by chronic hyperglycemia that promotes ROS formation, causing severe oxidative stress. Furthermore, prolonged hyperglycemia leads to glycation reactions with formation of AGEs that contribute to a chronic inflammatory state. This research aims to evaluate the inhib...

Descripción completa

Detalles Bibliográficos
Autores principales:	Djeujo, Francine Medjiofack, Francesconi, Valeria, Gonella, Maddalena, Ragazzi, Eugenio, Tonelli, Michele, Froldi, Guglielmina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777799/ https://www.ncbi.nlm.nih.gov/pubmed/35056861 http://dx.doi.org/10.3390/molecules27020547

Ejemplares similares

Comparative Evaluation of the Antiglycation and Anti-α-Glucosidase Activities of Baicalein, Baicalin (Baicalein 7-O-Glucuronide) and the Antidiabetic Drug Metformin
por: Froldi, Guglielmina, et al.
Publicado: (2022)

Magnolol and Luteolin Inhibition of α-Glucosidase Activity: Kinetics and Type of Interaction Detected by In Vitro and In Silico Studies
por: Djeujo, Francine Medjiofack, et al.
Publicado: (2022)

Luteolin and Vernodalol as Bioactive Compounds of Leaf and Root Vernonia amygdalina Extracts: Effects on α-Glucosidase, Glycation, ROS, Cell Viability, and In Silico ADMET Parameters
por: Djeujo, Francine Medjiofack, et al.
Publicado: (2023)

Pterodon emarginatus Seed Preparations: Antiradical Activity, Chemical Characterization, and In Silico ADMET Parameters of β-caryophyllene and Farnesol
por: Froldi, Guglielmina, et al.
Publicado: (2023)

Antiglycation Activity and HT-29 Cellular Uptake of Aloe-Emodin, Aloin, and Aloe arborescens Leaf Extracts
por: Froldi, Guglielmina, et al.
Publicado: (2019)

Selected Plant-Derived Polyphenols as Potential Therapeutic Agents for Peripheral Artery Disease: Molecular Mechanisms, Efficacy and Safety
por: Froldi, Guglielmina, et al.
Publicado: (2022)

In Silico Study of Mangostin Compounds and Its Derivatives as Inhibitors of α-Glucosidase Enzymes for Anti-Diabetic Studies
por: Maulana, Ahmad Fariz, et al.
Publicado: (2022)

α-Mangostin Extraction from the Native Mangosteen (Garcinia mangostana L.) and the Binding Mechanisms of α-Mangostin to HSA or TRF
por: Guo, Ming, et al.
Publicado: (2016)

Nanoparticle Drug Delivery Systems for α-Mangostin
por: Wathoni, Nasrul, et al.
Publicado: (2020)

α-Mangostin Inhibits α-Synuclein-Induced Microglial Neuroinflammation and Neurotoxicity
por: Hu, Zhaoyang, et al.
Publicado: (2016)

α-Mangostin from Cratoxylum arborescens (Vahl) Blume Demonstrates Anti-Ulcerogenic Property: A Mechanistic Study
por: Sidahmed, Heyam M. A., et al.
Publicado: (2013)

Nanoformulations of α-Mangostin for Cancer Drug Delivery System
por: Meylina, Lisna, et al.
Publicado: (2021)

Antimicrobial activity of α-mangostin against Staphylococcus species from companion animals in vitro and therapeutic potential of α-mangostin in skin diseases caused by S. pseudintermedius
por: Park, Seong Yong, et al.
Publicado: (2023)

Functional selectivity of EM-2 analogs at the mu-opioid receptor
por: Piekielna-Ciesielska, Justyna, et al.
Publicado: (2023)

Synthesis of nano-α mangostin based on chitosan and Eudragit S 100
por: Herdiana, Yedi, et al.
Publicado: (2020)

The purity identification and radiolabeling of α-mangostin with technetium-99m
por: Muchtaridi, Muchtaridi, et al.
Publicado: (2020)

Water-dispersible unadulterated α-mangostin particles for biomedical applications
por: Bumrung, Jutamad, et al.
Publicado: (2020)

Antimicrobial and Anti-inflammatory Effects of α-Mangostin Soluble Film
por: Tangsuksan, Piyawat, et al.
Publicado: (2022)

The Effect of α-Mangostin and Cisplatin on Ovarian Cancer Cells and the Microenvironment
por: Borzdziłowska, Paulina, et al.
Publicado: (2022)

The metabolic and molecular mechanisms of α-mangostin in cardiometabolic disorders (Review)
por: John, Oliver Dean, et al.
Publicado: (2022)

Necrosis in non-tumour tissues caused by flavone acetic acid and 5,6-dimethyl xanthenone acetic acid.
por: Zwi, L. J., et al.
Publicado: (1990)

The Use of Medicinal Plants in Blood Vessel Diseases: The Influence of Gender
por: Froldi, Guglielmina
Publicado: (2023)

in Vitro and in Vivo Inhibitory Effects of α-Mangostin on Cholangiocarcinoma Cells and Allografts
por: Aukkanimart, Ratchadawan, et al.
Publicado: (2017)

α-Mangostin/γ-Cyclodextrin Inclusion Complex: Formation and Thermodynamic Study
por: Suharyani, Ine, et al.
Publicado: (2021)

Characterization of Novel α-Mangostin and Paeonol Derivatives With Cancer-Selective Cytotoxicity
por: Nunna, Suneetha, et al.
Publicado: (2022)

Fishing of α-Glucosidase’s Ligands from Aloe vera by α-Glucosidase Functionalized Magnetic Nanoparticles
por: Yuan, Hao, et al.
Publicado: (2021)

Inhibition on α-Glucosidase Activity and Non-Enzymatic Glycation by an Anti-Oxidative Proteoglycan from Ganoderma lucidum
por: Zhang, Ying, et al.
Publicado: (2022)

Synergic Effect of α-Mangostin on the Cytotoxicity of Cisplatin in a Cervical Cancer Model
por: Pérez-Rojas, Jazmin M., et al.
Publicado: (2016)

Nanocarrier-mediated delivery of α-mangostin for non-surgical castration of male animals
por: Yostawonkul, Jakarwan, et al.
Publicado: (2017)

Using high-throughput sequencing to explore the anti-inflammatory effects of α-mangostin
por: Yin, Peng, et al.
Publicado: (2019)

Momilactones A and B Are α-Amylase and α-Glucosidase Inhibitors
por: Quan, Nguyen Van, et al.
Publicado: (2019)

Dietary Polyphenols as Natural Inhibitors of α-Amylase and α-Glucosidase
por: Ćorković, Ina, et al.
Publicado: (2022)

Endothelial dysfunction in Coronavirus disease 2019 (COVID-19): Gender and age influences
por: Froldi, Guglielmina, et al.
Publicado: (2020)

Identification of Bioactive Phytochemicals from Six Plants: Mechanistic Insights into the Inhibition of Rumen Protozoa, Ammoniagenesis, and α-Glucosidase
por: Ayemele, Aurele Gnetegha, et al.
Publicado: (2021)

Comprehensive enzymatic analysis of the amylolytic system in the digestive fluid of the sea hare, Aplysia kurodai: Unique properties of two α-amylases and two α-glucosidases
por: Tsuji, Akihiko, et al.
Publicado: (2014)

α-Mangostin Alleviated HIF-1α-Mediated Angiogenesis in Rats With Adjuvant-Induced Arthritis by Suppressing Aerobic Glycolysis
por: Jiang, Tian-Tian, et al.
Publicado: (2021)

Bioactivities of β-mangostin and its new glycoside derivatives synthesized by enzymatic reactions
por: Le, Tuoi Thi, et al.
Publicado: (2023)

α-Mangostin Reduced ER Stress-mediated Tumor Growth through Autophagy Activation
por: Kim, Sung-Jin, et al.
Publicado: (2012)

α-Mangostin Disrupts the Development of Streptococcus mutans Biofilms and Facilitates Its Mechanical Removal
por: Nguyen, Phuong Thi Mai, et al.
Publicado: (2014)

Co-solvation effect on the binding mode of the α-mangostin/β-cyclodextrin inclusion complex
por: Rungnim, Chompoonut, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_to4ovq6943dhbgsnrobvg8kohg