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Obesity and Metabolic Dysregulation in Children Provide Protective Influenza Vaccine Responses

The most effective intervention for influenza prevention is vaccination. However, there are conflicting data on influenza vaccine antibody responses in obese children. Cardio-metabolic parameters such as waist circumference, cholesterol, insulin sensitivity, and blood pressure are used to subdivide...

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Autores principales: Kainth, Mundeep K., Fishbein, Joanna S., Aydillo, Teresa, Escalera, Alba, Odusanya, Rachael, Grammatikopoulos, Kalliopi, Scotto, Tiffany, Sethna, Christine B., García-Sastre, Adolfo, Deutschman, Clifford S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777815/
https://www.ncbi.nlm.nih.gov/pubmed/35062328
http://dx.doi.org/10.3390/v14010124
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author Kainth, Mundeep K.
Fishbein, Joanna S.
Aydillo, Teresa
Escalera, Alba
Odusanya, Rachael
Grammatikopoulos, Kalliopi
Scotto, Tiffany
Sethna, Christine B.
García-Sastre, Adolfo
Deutschman, Clifford S.
author_facet Kainth, Mundeep K.
Fishbein, Joanna S.
Aydillo, Teresa
Escalera, Alba
Odusanya, Rachael
Grammatikopoulos, Kalliopi
Scotto, Tiffany
Sethna, Christine B.
García-Sastre, Adolfo
Deutschman, Clifford S.
author_sort Kainth, Mundeep K.
collection PubMed
description The most effective intervention for influenza prevention is vaccination. However, there are conflicting data on influenza vaccine antibody responses in obese children. Cardio-metabolic parameters such as waist circumference, cholesterol, insulin sensitivity, and blood pressure are used to subdivide individuals with overweight or obese BMI into ‘healthy’ (MHOO) or ‘unhealthy’ (MUOO) metabolic phenotypes. The ever-evolving metabolic phenotypes in children may be elucidated by using vaccine stimulation to characterize cytokine responses. We conducted a prospective cohort study evaluating influenza vaccine responses in children. Participants were identified as either normal-weight children (NWC) or overweight/obese using BMI. Children with obesity were then characterized using metabolic health metrics. These metrics consisted of changes in serum cytokine and chemokine concentrations measured via multiplex assay at baseline and repeated at one month following vaccination. Changes in NWC, MHOO and MUOO were compared using Chi-square/Fisher’s exact test for antibody responses and Kruskal–Wallis test for cytokines. Differences in influenza antibody responses in normal, MHOO and MUOO children were statistically indistinguishable. IL-13 was decreased in MUOO children compared to NWC and MHOO children (p = 0.04). IL-10 approached a statistically significant decrease in MUOO compared to MHOO and NWC (p = 0.07). Influenza vaccination does not provoke different responses in NCW, MHOO, or MUOO children, suggesting that obesity, whether metabolically healthy or unhealthy, does not alter the efficacy of vaccination. IL-13 levels in MUO children were significantly different from levels in normal and MHOO children, indicating that the metabolically unhealthy phenotypes may be associated with an altered inflammatory response. A larger sample size with greater numbers of metabolically unhealthy children may lend more insight into the relationship of chronic inflammation secondary to obesity with vaccine immunity.
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spelling pubmed-87778152022-01-22 Obesity and Metabolic Dysregulation in Children Provide Protective Influenza Vaccine Responses Kainth, Mundeep K. Fishbein, Joanna S. Aydillo, Teresa Escalera, Alba Odusanya, Rachael Grammatikopoulos, Kalliopi Scotto, Tiffany Sethna, Christine B. García-Sastre, Adolfo Deutschman, Clifford S. Viruses Article The most effective intervention for influenza prevention is vaccination. However, there are conflicting data on influenza vaccine antibody responses in obese children. Cardio-metabolic parameters such as waist circumference, cholesterol, insulin sensitivity, and blood pressure are used to subdivide individuals with overweight or obese BMI into ‘healthy’ (MHOO) or ‘unhealthy’ (MUOO) metabolic phenotypes. The ever-evolving metabolic phenotypes in children may be elucidated by using vaccine stimulation to characterize cytokine responses. We conducted a prospective cohort study evaluating influenza vaccine responses in children. Participants were identified as either normal-weight children (NWC) or overweight/obese using BMI. Children with obesity were then characterized using metabolic health metrics. These metrics consisted of changes in serum cytokine and chemokine concentrations measured via multiplex assay at baseline and repeated at one month following vaccination. Changes in NWC, MHOO and MUOO were compared using Chi-square/Fisher’s exact test for antibody responses and Kruskal–Wallis test for cytokines. Differences in influenza antibody responses in normal, MHOO and MUOO children were statistically indistinguishable. IL-13 was decreased in MUOO children compared to NWC and MHOO children (p = 0.04). IL-10 approached a statistically significant decrease in MUOO compared to MHOO and NWC (p = 0.07). Influenza vaccination does not provoke different responses in NCW, MHOO, or MUOO children, suggesting that obesity, whether metabolically healthy or unhealthy, does not alter the efficacy of vaccination. IL-13 levels in MUO children were significantly different from levels in normal and MHOO children, indicating that the metabolically unhealthy phenotypes may be associated with an altered inflammatory response. A larger sample size with greater numbers of metabolically unhealthy children may lend more insight into the relationship of chronic inflammation secondary to obesity with vaccine immunity. MDPI 2022-01-11 /pmc/articles/PMC8777815/ /pubmed/35062328 http://dx.doi.org/10.3390/v14010124 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kainth, Mundeep K.
Fishbein, Joanna S.
Aydillo, Teresa
Escalera, Alba
Odusanya, Rachael
Grammatikopoulos, Kalliopi
Scotto, Tiffany
Sethna, Christine B.
García-Sastre, Adolfo
Deutschman, Clifford S.
Obesity and Metabolic Dysregulation in Children Provide Protective Influenza Vaccine Responses
title Obesity and Metabolic Dysregulation in Children Provide Protective Influenza Vaccine Responses
title_full Obesity and Metabolic Dysregulation in Children Provide Protective Influenza Vaccine Responses
title_fullStr Obesity and Metabolic Dysregulation in Children Provide Protective Influenza Vaccine Responses
title_full_unstemmed Obesity and Metabolic Dysregulation in Children Provide Protective Influenza Vaccine Responses
title_short Obesity and Metabolic Dysregulation in Children Provide Protective Influenza Vaccine Responses
title_sort obesity and metabolic dysregulation in children provide protective influenza vaccine responses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777815/
https://www.ncbi.nlm.nih.gov/pubmed/35062328
http://dx.doi.org/10.3390/v14010124
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