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Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction

The optimal heart rate (HR) in patients with heart failure with reduced ejection fraction (HFrEF) has been ill-defined. Recently, a formula was proposed for estimating the target heart rate (THR), which eliminates the overlap between the E and A wave (E-A overlap). We aim to validate its prognostic...

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Autores principales: Yumita, Yusuke, Nagatomo, Yuji, Takei, Makoto, Saji, Mike, Goda, Ayumi, Kohno, Takashi, Nakano, Shintaro, Nishihata, Yosuke, Ikegami, Yukinori, Shiraishi, Yasuyuki, Kohsaka, Shun, Adachi, Takeshi, Yoshikawa, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777886/
https://www.ncbi.nlm.nih.gov/pubmed/35055365
http://dx.doi.org/10.3390/jpm12010050
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author Yumita, Yusuke
Nagatomo, Yuji
Takei, Makoto
Saji, Mike
Goda, Ayumi
Kohno, Takashi
Nakano, Shintaro
Nishihata, Yosuke
Ikegami, Yukinori
Shiraishi, Yasuyuki
Kohsaka, Shun
Adachi, Takeshi
Yoshikawa, Tsutomu
author_facet Yumita, Yusuke
Nagatomo, Yuji
Takei, Makoto
Saji, Mike
Goda, Ayumi
Kohno, Takashi
Nakano, Shintaro
Nishihata, Yosuke
Ikegami, Yukinori
Shiraishi, Yasuyuki
Kohsaka, Shun
Adachi, Takeshi
Yoshikawa, Tsutomu
author_sort Yumita, Yusuke
collection PubMed
description The optimal heart rate (HR) in patients with heart failure with reduced ejection fraction (HFrEF) has been ill-defined. Recently, a formula was proposed for estimating the target heart rate (THR), which eliminates the overlap between the E and A wave (E-A overlap). We aim to validate its prognostic significance in the multicenter WET-HF registry. This study used data from 647 patients with HFrEF hospitalized for acute decompensated HF (ADHF). The patients were divided into the 2 groups by THR. The primary endpoint was defined as the composite of all-cause death and ADHF readmission. The THR successfully discriminated the incidence of the primary endpoint, whereas no significant difference was observed in the primary endpoint when dividing the patients by uniform cutoff 70 bpm. HR at discharge ≤ THR was inversely associated with the primary endpoint. Restricted cubic spline analysis demonstrated the difference between HR at discharge, and THR (ΔHR) from −10 to ±0 was associated with a lower risk of primary endpoint and ΔHR from ±0 to +15 was associated with a higher risk. THR discriminated long-term outcomes in patients with HFrEF more efficiently than the uniform cutoff, suggesting that it may aid in tailored HR reduction strategies.
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spelling pubmed-87778862022-01-22 Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction Yumita, Yusuke Nagatomo, Yuji Takei, Makoto Saji, Mike Goda, Ayumi Kohno, Takashi Nakano, Shintaro Nishihata, Yosuke Ikegami, Yukinori Shiraishi, Yasuyuki Kohsaka, Shun Adachi, Takeshi Yoshikawa, Tsutomu J Pers Med Article The optimal heart rate (HR) in patients with heart failure with reduced ejection fraction (HFrEF) has been ill-defined. Recently, a formula was proposed for estimating the target heart rate (THR), which eliminates the overlap between the E and A wave (E-A overlap). We aim to validate its prognostic significance in the multicenter WET-HF registry. This study used data from 647 patients with HFrEF hospitalized for acute decompensated HF (ADHF). The patients were divided into the 2 groups by THR. The primary endpoint was defined as the composite of all-cause death and ADHF readmission. The THR successfully discriminated the incidence of the primary endpoint, whereas no significant difference was observed in the primary endpoint when dividing the patients by uniform cutoff 70 bpm. HR at discharge ≤ THR was inversely associated with the primary endpoint. Restricted cubic spline analysis demonstrated the difference between HR at discharge, and THR (ΔHR) from −10 to ±0 was associated with a lower risk of primary endpoint and ΔHR from ±0 to +15 was associated with a higher risk. THR discriminated long-term outcomes in patients with HFrEF more efficiently than the uniform cutoff, suggesting that it may aid in tailored HR reduction strategies. MDPI 2022-01-05 /pmc/articles/PMC8777886/ /pubmed/35055365 http://dx.doi.org/10.3390/jpm12010050 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yumita, Yusuke
Nagatomo, Yuji
Takei, Makoto
Saji, Mike
Goda, Ayumi
Kohno, Takashi
Nakano, Shintaro
Nishihata, Yosuke
Ikegami, Yukinori
Shiraishi, Yasuyuki
Kohsaka, Shun
Adachi, Takeshi
Yoshikawa, Tsutomu
Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction
title Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction
title_full Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction
title_fullStr Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction
title_full_unstemmed Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction
title_short Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction
title_sort personalized target heart rate for patients with heart failure and reduced ejection fraction
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777886/
https://www.ncbi.nlm.nih.gov/pubmed/35055365
http://dx.doi.org/10.3390/jpm12010050
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