Cargando…
Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction
The optimal heart rate (HR) in patients with heart failure with reduced ejection fraction (HFrEF) has been ill-defined. Recently, a formula was proposed for estimating the target heart rate (THR), which eliminates the overlap between the E and A wave (E-A overlap). We aim to validate its prognostic...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777886/ https://www.ncbi.nlm.nih.gov/pubmed/35055365 http://dx.doi.org/10.3390/jpm12010050 |
_version_ | 1784637180250947584 |
---|---|
author | Yumita, Yusuke Nagatomo, Yuji Takei, Makoto Saji, Mike Goda, Ayumi Kohno, Takashi Nakano, Shintaro Nishihata, Yosuke Ikegami, Yukinori Shiraishi, Yasuyuki Kohsaka, Shun Adachi, Takeshi Yoshikawa, Tsutomu |
author_facet | Yumita, Yusuke Nagatomo, Yuji Takei, Makoto Saji, Mike Goda, Ayumi Kohno, Takashi Nakano, Shintaro Nishihata, Yosuke Ikegami, Yukinori Shiraishi, Yasuyuki Kohsaka, Shun Adachi, Takeshi Yoshikawa, Tsutomu |
author_sort | Yumita, Yusuke |
collection | PubMed |
description | The optimal heart rate (HR) in patients with heart failure with reduced ejection fraction (HFrEF) has been ill-defined. Recently, a formula was proposed for estimating the target heart rate (THR), which eliminates the overlap between the E and A wave (E-A overlap). We aim to validate its prognostic significance in the multicenter WET-HF registry. This study used data from 647 patients with HFrEF hospitalized for acute decompensated HF (ADHF). The patients were divided into the 2 groups by THR. The primary endpoint was defined as the composite of all-cause death and ADHF readmission. The THR successfully discriminated the incidence of the primary endpoint, whereas no significant difference was observed in the primary endpoint when dividing the patients by uniform cutoff 70 bpm. HR at discharge ≤ THR was inversely associated with the primary endpoint. Restricted cubic spline analysis demonstrated the difference between HR at discharge, and THR (ΔHR) from −10 to ±0 was associated with a lower risk of primary endpoint and ΔHR from ±0 to +15 was associated with a higher risk. THR discriminated long-term outcomes in patients with HFrEF more efficiently than the uniform cutoff, suggesting that it may aid in tailored HR reduction strategies. |
format | Online Article Text |
id | pubmed-8777886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87778862022-01-22 Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction Yumita, Yusuke Nagatomo, Yuji Takei, Makoto Saji, Mike Goda, Ayumi Kohno, Takashi Nakano, Shintaro Nishihata, Yosuke Ikegami, Yukinori Shiraishi, Yasuyuki Kohsaka, Shun Adachi, Takeshi Yoshikawa, Tsutomu J Pers Med Article The optimal heart rate (HR) in patients with heart failure with reduced ejection fraction (HFrEF) has been ill-defined. Recently, a formula was proposed for estimating the target heart rate (THR), which eliminates the overlap between the E and A wave (E-A overlap). We aim to validate its prognostic significance in the multicenter WET-HF registry. This study used data from 647 patients with HFrEF hospitalized for acute decompensated HF (ADHF). The patients were divided into the 2 groups by THR. The primary endpoint was defined as the composite of all-cause death and ADHF readmission. The THR successfully discriminated the incidence of the primary endpoint, whereas no significant difference was observed in the primary endpoint when dividing the patients by uniform cutoff 70 bpm. HR at discharge ≤ THR was inversely associated with the primary endpoint. Restricted cubic spline analysis demonstrated the difference between HR at discharge, and THR (ΔHR) from −10 to ±0 was associated with a lower risk of primary endpoint and ΔHR from ±0 to +15 was associated with a higher risk. THR discriminated long-term outcomes in patients with HFrEF more efficiently than the uniform cutoff, suggesting that it may aid in tailored HR reduction strategies. MDPI 2022-01-05 /pmc/articles/PMC8777886/ /pubmed/35055365 http://dx.doi.org/10.3390/jpm12010050 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yumita, Yusuke Nagatomo, Yuji Takei, Makoto Saji, Mike Goda, Ayumi Kohno, Takashi Nakano, Shintaro Nishihata, Yosuke Ikegami, Yukinori Shiraishi, Yasuyuki Kohsaka, Shun Adachi, Takeshi Yoshikawa, Tsutomu Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction |
title | Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction |
title_full | Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction |
title_fullStr | Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction |
title_full_unstemmed | Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction |
title_short | Personalized Target Heart Rate for Patients with Heart Failure and Reduced Ejection Fraction |
title_sort | personalized target heart rate for patients with heart failure and reduced ejection fraction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777886/ https://www.ncbi.nlm.nih.gov/pubmed/35055365 http://dx.doi.org/10.3390/jpm12010050 |
work_keys_str_mv | AT yumitayusuke personalizedtargetheartrateforpatientswithheartfailureandreducedejectionfraction AT nagatomoyuji personalizedtargetheartrateforpatientswithheartfailureandreducedejectionfraction AT takeimakoto personalizedtargetheartrateforpatientswithheartfailureandreducedejectionfraction AT sajimike personalizedtargetheartrateforpatientswithheartfailureandreducedejectionfraction AT godaayumi personalizedtargetheartrateforpatientswithheartfailureandreducedejectionfraction AT kohnotakashi personalizedtargetheartrateforpatientswithheartfailureandreducedejectionfraction AT nakanoshintaro personalizedtargetheartrateforpatientswithheartfailureandreducedejectionfraction AT nishihatayosuke personalizedtargetheartrateforpatientswithheartfailureandreducedejectionfraction AT ikegamiyukinori personalizedtargetheartrateforpatientswithheartfailureandreducedejectionfraction AT shiraishiyasuyuki personalizedtargetheartrateforpatientswithheartfailureandreducedejectionfraction AT kohsakashun personalizedtargetheartrateforpatientswithheartfailureandreducedejectionfraction AT adachitakeshi personalizedtargetheartrateforpatientswithheartfailureandreducedejectionfraction AT yoshikawatsutomu personalizedtargetheartrateforpatientswithheartfailureandreducedejectionfraction |