Cargando…

Effectiveness and Efficacy of Vaccine on Mutated SARS-CoV-2 Virus and Post Vaccination Surveillance: A Narrative Review

The ongoing COVID-19 pandemic, as a result of the SARS-CoV-2 virus, since December 2019, is a major health problem and concern worldwide. The pandemic has impacted various fields, from the social to the development of health science and technology. The virus has been mutating and thus producing seve...

Descripción completa

Detalles Bibliográficos
Autores principales: Hafiz, Ihsanul, Illian, Didi Nurhadi, Meila, Okpri, Utomo, Ahmad Rusdan Handoyo, Susilowati, Arida, Susetya, Ipanna Enggar, Desrita, Desrita, Siregar, Gontar Alamsyah, Basyuni, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777947/
https://www.ncbi.nlm.nih.gov/pubmed/35062743
http://dx.doi.org/10.3390/vaccines10010082
_version_ 1784637196157845504
author Hafiz, Ihsanul
Illian, Didi Nurhadi
Meila, Okpri
Utomo, Ahmad Rusdan Handoyo
Susilowati, Arida
Susetya, Ipanna Enggar
Desrita, Desrita
Siregar, Gontar Alamsyah
Basyuni, Mohammad
author_facet Hafiz, Ihsanul
Illian, Didi Nurhadi
Meila, Okpri
Utomo, Ahmad Rusdan Handoyo
Susilowati, Arida
Susetya, Ipanna Enggar
Desrita, Desrita
Siregar, Gontar Alamsyah
Basyuni, Mohammad
author_sort Hafiz, Ihsanul
collection PubMed
description The ongoing COVID-19 pandemic, as a result of the SARS-CoV-2 virus, since December 2019, is a major health problem and concern worldwide. The pandemic has impacted various fields, from the social to the development of health science and technology. The virus has been mutating and thus producing several new variants, rushing research in the field of molecular biology to develop rapidly to overcome the problems that occur. Vaccine clinical studies are developing promptly with the aim of obtaining vaccines that are effective in suppressing the spread of the virus; however, the development of viral mutations raises concerns about the decreasing effectiveness of the resulting vaccine, which also results in the need for more in-depth studies. There have been 330 vaccines developed, including 136 clinical developments and 194 pre-clinical developments. The SARS-CoV-2 variant continues to evolve today, and it poses a challenge in testing the effectiveness of existing vaccines. This is a narrative review describing the emergence of the COVID-19 pandemic, development of vaccine platforms, identification of concerning mutations and virus variants in various countries of the world, and real-world monitoring of post-vaccination effectiveness and surveillance.
format Online
Article
Text
id pubmed-8777947
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87779472022-01-22 Effectiveness and Efficacy of Vaccine on Mutated SARS-CoV-2 Virus and Post Vaccination Surveillance: A Narrative Review Hafiz, Ihsanul Illian, Didi Nurhadi Meila, Okpri Utomo, Ahmad Rusdan Handoyo Susilowati, Arida Susetya, Ipanna Enggar Desrita, Desrita Siregar, Gontar Alamsyah Basyuni, Mohammad Vaccines (Basel) Review The ongoing COVID-19 pandemic, as a result of the SARS-CoV-2 virus, since December 2019, is a major health problem and concern worldwide. The pandemic has impacted various fields, from the social to the development of health science and technology. The virus has been mutating and thus producing several new variants, rushing research in the field of molecular biology to develop rapidly to overcome the problems that occur. Vaccine clinical studies are developing promptly with the aim of obtaining vaccines that are effective in suppressing the spread of the virus; however, the development of viral mutations raises concerns about the decreasing effectiveness of the resulting vaccine, which also results in the need for more in-depth studies. There have been 330 vaccines developed, including 136 clinical developments and 194 pre-clinical developments. The SARS-CoV-2 variant continues to evolve today, and it poses a challenge in testing the effectiveness of existing vaccines. This is a narrative review describing the emergence of the COVID-19 pandemic, development of vaccine platforms, identification of concerning mutations and virus variants in various countries of the world, and real-world monitoring of post-vaccination effectiveness and surveillance. MDPI 2022-01-06 /pmc/articles/PMC8777947/ /pubmed/35062743 http://dx.doi.org/10.3390/vaccines10010082 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hafiz, Ihsanul
Illian, Didi Nurhadi
Meila, Okpri
Utomo, Ahmad Rusdan Handoyo
Susilowati, Arida
Susetya, Ipanna Enggar
Desrita, Desrita
Siregar, Gontar Alamsyah
Basyuni, Mohammad
Effectiveness and Efficacy of Vaccine on Mutated SARS-CoV-2 Virus and Post Vaccination Surveillance: A Narrative Review
title Effectiveness and Efficacy of Vaccine on Mutated SARS-CoV-2 Virus and Post Vaccination Surveillance: A Narrative Review
title_full Effectiveness and Efficacy of Vaccine on Mutated SARS-CoV-2 Virus and Post Vaccination Surveillance: A Narrative Review
title_fullStr Effectiveness and Efficacy of Vaccine on Mutated SARS-CoV-2 Virus and Post Vaccination Surveillance: A Narrative Review
title_full_unstemmed Effectiveness and Efficacy of Vaccine on Mutated SARS-CoV-2 Virus and Post Vaccination Surveillance: A Narrative Review
title_short Effectiveness and Efficacy of Vaccine on Mutated SARS-CoV-2 Virus and Post Vaccination Surveillance: A Narrative Review
title_sort effectiveness and efficacy of vaccine on mutated sars-cov-2 virus and post vaccination surveillance: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777947/
https://www.ncbi.nlm.nih.gov/pubmed/35062743
http://dx.doi.org/10.3390/vaccines10010082
work_keys_str_mv AT hafizihsanul effectivenessandefficacyofvaccineonmutatedsarscov2virusandpostvaccinationsurveillanceanarrativereview
AT illiandidinurhadi effectivenessandefficacyofvaccineonmutatedsarscov2virusandpostvaccinationsurveillanceanarrativereview
AT meilaokpri effectivenessandefficacyofvaccineonmutatedsarscov2virusandpostvaccinationsurveillanceanarrativereview
AT utomoahmadrusdanhandoyo effectivenessandefficacyofvaccineonmutatedsarscov2virusandpostvaccinationsurveillanceanarrativereview
AT susilowatiarida effectivenessandefficacyofvaccineonmutatedsarscov2virusandpostvaccinationsurveillanceanarrativereview
AT susetyaipannaenggar effectivenessandefficacyofvaccineonmutatedsarscov2virusandpostvaccinationsurveillanceanarrativereview
AT desritadesrita effectivenessandefficacyofvaccineonmutatedsarscov2virusandpostvaccinationsurveillanceanarrativereview
AT siregargontaralamsyah effectivenessandefficacyofvaccineonmutatedsarscov2virusandpostvaccinationsurveillanceanarrativereview
AT basyunimohammad effectivenessandefficacyofvaccineonmutatedsarscov2virusandpostvaccinationsurveillanceanarrativereview