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P2X7 Receptor Antagonist Reduces Fibrosis and Inflammation in a Mouse Model of Alpha-Sarcoglycan Muscular Dystrophy

Limb-girdle muscular dystrophy R3, a rare genetic disorder affecting the limb proximal muscles, is caused by mutations in the α-sarcoglycan gene (Sgca) and aggravated by an immune-mediated damage, finely modulated by the extracellular (e)ATP/purinoceptors axis. Currently, no specific drugs are avail...

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Detalles Bibliográficos
Autores principales:	Raffaghello, Lizzia, Principi, Elisa, Baratto, Serena, Panicucci, Chiara, Pintus, Sara, Antonini, Francesca, Del Zotto, Genny, Benzi, Andrea, Bruzzone, Santina, Scudieri, Paolo, Minetti, Carlo, Gazzerro, Elisabetta, Bruno, Claudio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8777980/ https://www.ncbi.nlm.nih.gov/pubmed/35056146 http://dx.doi.org/10.3390/ph15010089

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