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Replication and Spread of Oncolytic Herpes Simplex Virus in Solid Tumors
Oncolytic herpes simplex virus (oHSV) is a highly promising treatment for solid tumors. Intense research and development efforts have led to first-in-class approval for an oHSV for melanoma, but barriers to this promising therapy still exist that limit efficacy. The process of infection, replication...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778098/ https://www.ncbi.nlm.nih.gov/pubmed/35062322 http://dx.doi.org/10.3390/v14010118 |
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author | Hong, Bangxing Sahu, Upasana Mullarkey, Matthew P. Kaur, Balveen |
author_facet | Hong, Bangxing Sahu, Upasana Mullarkey, Matthew P. Kaur, Balveen |
author_sort | Hong, Bangxing |
collection | PubMed |
description | Oncolytic herpes simplex virus (oHSV) is a highly promising treatment for solid tumors. Intense research and development efforts have led to first-in-class approval for an oHSV for melanoma, but barriers to this promising therapy still exist that limit efficacy. The process of infection, replication and transmission of oHSV in solid tumors is key to obtaining a good lytic destruction of infected cancer cells to kill tumor cells and release tumor antigens that can prime anti-tumor efficacy. Intracellular tumor cell signaling and tumor stromal cells present multiple barriers that resist oHSV activity. Here, we provide a review focused on oncolytic HSV and the essential viral genes that allow for virus replication and spread in order to gain insight into how manipulation of these pathways can be exploited to potentiate oHSV infection and replication among tumor cells. |
format | Online Article Text |
id | pubmed-8778098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87780982022-01-22 Replication and Spread of Oncolytic Herpes Simplex Virus in Solid Tumors Hong, Bangxing Sahu, Upasana Mullarkey, Matthew P. Kaur, Balveen Viruses Review Oncolytic herpes simplex virus (oHSV) is a highly promising treatment for solid tumors. Intense research and development efforts have led to first-in-class approval for an oHSV for melanoma, but barriers to this promising therapy still exist that limit efficacy. The process of infection, replication and transmission of oHSV in solid tumors is key to obtaining a good lytic destruction of infected cancer cells to kill tumor cells and release tumor antigens that can prime anti-tumor efficacy. Intracellular tumor cell signaling and tumor stromal cells present multiple barriers that resist oHSV activity. Here, we provide a review focused on oncolytic HSV and the essential viral genes that allow for virus replication and spread in order to gain insight into how manipulation of these pathways can be exploited to potentiate oHSV infection and replication among tumor cells. MDPI 2022-01-10 /pmc/articles/PMC8778098/ /pubmed/35062322 http://dx.doi.org/10.3390/v14010118 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hong, Bangxing Sahu, Upasana Mullarkey, Matthew P. Kaur, Balveen Replication and Spread of Oncolytic Herpes Simplex Virus in Solid Tumors |
title | Replication and Spread of Oncolytic Herpes Simplex Virus in Solid Tumors |
title_full | Replication and Spread of Oncolytic Herpes Simplex Virus in Solid Tumors |
title_fullStr | Replication and Spread of Oncolytic Herpes Simplex Virus in Solid Tumors |
title_full_unstemmed | Replication and Spread of Oncolytic Herpes Simplex Virus in Solid Tumors |
title_short | Replication and Spread of Oncolytic Herpes Simplex Virus in Solid Tumors |
title_sort | replication and spread of oncolytic herpes simplex virus in solid tumors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778098/ https://www.ncbi.nlm.nih.gov/pubmed/35062322 http://dx.doi.org/10.3390/v14010118 |
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