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The Role of Mitochondrial DNA Mutations in Cardiovascular Diseases

Cardiovascular diseases (CVD) are one of the leading causes of morbidity and mortality worldwide. mtDNA (mitochondrial DNA) mutations are known to participate in the development and progression of some CVD. Moreover, specific types of mitochondria-mediated CVD have been discovered, such as MIEH (mat...

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Autores principales: Dabravolski, Siarhei A., Khotina, Victoria A., Sukhorukov, Vasily N., Kalmykov, Vladislav A., Mikhaleva, Liudmila M., Orekhov, Alexander N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778138/
https://www.ncbi.nlm.nih.gov/pubmed/35055137
http://dx.doi.org/10.3390/ijms23020952
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author Dabravolski, Siarhei A.
Khotina, Victoria A.
Sukhorukov, Vasily N.
Kalmykov, Vladislav A.
Mikhaleva, Liudmila M.
Orekhov, Alexander N.
author_facet Dabravolski, Siarhei A.
Khotina, Victoria A.
Sukhorukov, Vasily N.
Kalmykov, Vladislav A.
Mikhaleva, Liudmila M.
Orekhov, Alexander N.
author_sort Dabravolski, Siarhei A.
collection PubMed
description Cardiovascular diseases (CVD) are one of the leading causes of morbidity and mortality worldwide. mtDNA (mitochondrial DNA) mutations are known to participate in the development and progression of some CVD. Moreover, specific types of mitochondria-mediated CVD have been discovered, such as MIEH (maternally inherited essential hypertension) and maternally inherited CHD (coronary heart disease). Maternally inherited mitochondrial CVD is caused by certain mutations in the mtDNA, which encode structural mitochondrial proteins and mitochondrial tRNA. In this review, we focus on recently identified mtDNA mutations associated with CVD (coronary artery disease and hypertension). Additionally, new data suggest the role of mtDNA mutations in Brugada syndrome and ischemic stroke, which before were considered only as a result of mutations in nuclear genes. Moreover, we discuss the molecular mechanisms of mtDNA involvement in the development of the disease.
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spelling pubmed-87781382022-01-22 The Role of Mitochondrial DNA Mutations in Cardiovascular Diseases Dabravolski, Siarhei A. Khotina, Victoria A. Sukhorukov, Vasily N. Kalmykov, Vladislav A. Mikhaleva, Liudmila M. Orekhov, Alexander N. Int J Mol Sci Review Cardiovascular diseases (CVD) are one of the leading causes of morbidity and mortality worldwide. mtDNA (mitochondrial DNA) mutations are known to participate in the development and progression of some CVD. Moreover, specific types of mitochondria-mediated CVD have been discovered, such as MIEH (maternally inherited essential hypertension) and maternally inherited CHD (coronary heart disease). Maternally inherited mitochondrial CVD is caused by certain mutations in the mtDNA, which encode structural mitochondrial proteins and mitochondrial tRNA. In this review, we focus on recently identified mtDNA mutations associated with CVD (coronary artery disease and hypertension). Additionally, new data suggest the role of mtDNA mutations in Brugada syndrome and ischemic stroke, which before were considered only as a result of mutations in nuclear genes. Moreover, we discuss the molecular mechanisms of mtDNA involvement in the development of the disease. MDPI 2022-01-16 /pmc/articles/PMC8778138/ /pubmed/35055137 http://dx.doi.org/10.3390/ijms23020952 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dabravolski, Siarhei A.
Khotina, Victoria A.
Sukhorukov, Vasily N.
Kalmykov, Vladislav A.
Mikhaleva, Liudmila M.
Orekhov, Alexander N.
The Role of Mitochondrial DNA Mutations in Cardiovascular Diseases
title The Role of Mitochondrial DNA Mutations in Cardiovascular Diseases
title_full The Role of Mitochondrial DNA Mutations in Cardiovascular Diseases
title_fullStr The Role of Mitochondrial DNA Mutations in Cardiovascular Diseases
title_full_unstemmed The Role of Mitochondrial DNA Mutations in Cardiovascular Diseases
title_short The Role of Mitochondrial DNA Mutations in Cardiovascular Diseases
title_sort role of mitochondrial dna mutations in cardiovascular diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778138/
https://www.ncbi.nlm.nih.gov/pubmed/35055137
http://dx.doi.org/10.3390/ijms23020952
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